Saturday, July 5, 2025 7/5/2025

Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementia

Award Number: R35HL140024
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2018
PERIOD OF PERFORMANCE END DATE: 12/31/2023

Group Awards By:

View Award Description

Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementia - Abstract A major focus of our efforts is to understand the mechanistic basis and functional consequences of ATPsensitive potassium (KATP) ion channels in the cardiovascular system. There are contradictory reports of KATP channel involvement in Alzheimer's Disease (AD) pathogenesis, and we hypothesize that this is because of the involvement of different channels in neurons versus in cerebral blood vessels. We propose that blocking KATP channels in blood vessels specifically will be beneficial, and we propose to test this in AD model mice by precise genetic manipulation of cardiovascular KATP channels. If successful, these studies will form the background to the testing of relevant pharmacological approaches to CS therapy in animal models and in humans, with the ultimate goal of developing a specific therapy for CS and related pathologies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1 )
2024	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Cardiovascular Diseases Research	001	6	12/12/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2023	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	003	6	6/28/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	002	6	6/28/2024	NON-COMPETING CONTINUATION	-$1
2024	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Cardiovascular Diseases Research	000	6	12/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = -$1

Issue Date FY: 2023 ( Subtotal = $1,304,584 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	002	6	4/3/2023	SUPPLEMENT FOR EXPANSION	$389,584
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	001	6	3/3/2023	NON-COMPETING CONTINUATION	$91,500
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	000	6	1/12/2023	NON-COMPETING CONTINUATION	$823,500
														Subtotal = $1,304,584

Issue Date FY: 2022 ( Subtotal = $915,000 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	001	5	6/6/2022	NON-COMPETING CONTINUATION	$91,500
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	000	5	12/15/2021	NON-COMPETING CONTINUATION	$823,500
														Subtotal = $915,000

Issue Date FY: 2021 ( Subtotal = $915,000 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	001	4	6/3/2021	NON-COMPETING CONTINUATION	$91,500
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	000	4	1/27/2021	NON-COMPETING CONTINUATION	$823,500
														Subtotal = $915,000

Issue Date FY: 2020 ( Subtotal = $915,000 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	000	3	12/26/2019	NON-COMPETING CONTINUATION	$869,250
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	001	3	3/13/2020	NON-COMPETING CONTINUATION	$45,750
														Subtotal = $915,000

Issue Date FY: 2019 ( Subtotal = $915,000 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	001	2	5/9/2019	NON-COMPETING CONTINUATION	$0
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	000	2	2/8/2019	NON-COMPETING CONTINUATION	$915,000
														Subtotal = $915,000

Issue Date FY: 2018 ( Subtotal = $915,000 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cardiovascular Diseases Research	000	1	12/26/2017	NEW	$915,000
														Subtotal = $915,000

Grand Total All Awards = $5,879,583

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementia

Award Number: R35HL140024

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2018

PERIOD OF PERFORMANCE END DATE: 12/31/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer