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Structural/functional characterization of TGFB superfamily signaling and regulation

Award Number: R35GM161787
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2031

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Structural/functional characterization of TGFB superfamily signaling and regulation - Project Summary: The TGFb family of signaling ligands orchestrate numerous biological processes in fetal development and adult homeostasis. Aberrant signaling results in many human diseases, highlighting the need to better understand the molecular mechanisms of signaling and regulation. Ligands in the family are generally divided into three classes (TGFbs, Bone Morphogenetic Proteins or BMPs and Activins) and signal by directing the assembly of two Type I and two Type II serine/threonine kinase receptors. The laboratory uses a combination of structural biology, computational biology, biophysics, and cell-based signaling assays to investigate several fundamental areas of signaling and regulation within the broader TGFb family. We are focused on four overarching questions: What are variations to ligand-receptor interactions that support ligand selectivity? How do different prodomains regulate their corresponding ligand? What are the molecular mechanisms that allow heterodimers to form and how are the interaction of heterodimers with receptors different than homodimers? How do structurally dissimilar antagonists bind and modulate specific ligands? Our approaches will couple structural techniques, such as cryoEM, X-ray crystallography and HDX/MS with in vitro cell-based assays and biochemical interrogation. In addition, we are incorporating deep learning and artificial intelligence technology to enhance de novo protein design strategies. Structural and functional studies of prodomain-ligand and antagonist- ligand interactions will continue to improve our knowledge of the diverse molecular mechanisms that regulate TGFb ligands. Overall, our multi-faceted research program aims to unravel the complexities and governance of molecular interactions in the TGFβ family.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $756,933 )
2026	2026	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Biomedical Research and Research Training	000	1	4/8/2026	NEW	$756,933
														Subtotal = $756,933

Grand Total All Awards = $756,933

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Structural/functional characterization of TGFB superfamily signaling and regulation

Award Number: R35GM161787

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2031

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