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Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics

Award Number: R35GM161216
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2031

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Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics - This research proposal aims to decode the structural and molecular architecture of centriolar plaques (CPs), a non-centrosomal microtubule organizing center, in the context of atypical eukaryotic cell division. Using expansion microscopy (U-ExM), we will map CP composition and dynamics with high resolution investigating their roles in MTOC formation, cell polarity, and organelle segregation during division. Our approach integrates U-ExM with functional analyses, leveraging CRISPR-Cas9 technology to generate inducible knockdown cell lines. This strategy will reveal the localizations and roles of key CP components, including taxon-specific and conserved proteins, in supporting nuclear division and cellular organization. By advancing our understanding of CP architecture and function, this work will provide transformative insights into conserved and divergent principles of eukaryotic cell division, offering a comparative framework to explore cellular diversity across eukaryotes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $396,250 )
2026	2026	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Biomedical Research and Research Training	000	1	2/20/2026	NEW	$396,250
														Subtotal = $396,250

Grand Total All Awards = $396,250

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Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics

Award Number: R35GM161216

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2031

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