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Evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila

Award Number: R35GM156525
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/10/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2029

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Evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila - Adaptive transcriptome evolution likely underlies a substantial component of all adaptations. Here I propose to study two main types of transcriptome evolution using Drosophila. First, we will identify transcriptome novelties in Drosophila melanogaster, focusing on reproductive tissues. We will then investigate the functions of these novelties using CRISPR and RNAi to learn about the possible agents of selection acting on them. Second, we will investigate convergent local adaptation at the transcriptome level in two distantly related species, D. simulans and D.hydei, and identify the underlying regulatory basis to determine whether convergent expression adaptation has a shared genetic basis or whether it generally proceeds by different trajectories in different species. Finally, we will carry out a more general investigation of the role of directional selection in driving expression divergence between Drosophila species.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $483,000 )
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	2	12/23/2025	NON-COMPETING CONTINUATION	$434,700
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	001	2	3/11/2026	NON-COMPETING CONTINUATION	$48,300
														Subtotal = $483,000

Issue Date FY: 2025 ( Subtotal = $507,000 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	1	1/10/2025	NEW	$507,000
														Subtotal = $507,000

Grand Total All Awards = $990,000

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Evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila

Award Number: R35GM156525

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/10/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2029

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