Tuesday, July 1, 2025 7/1/2025

MIRA R35: Fibrin(ogen) in regulating health and disease

Award Number: R35GM155242
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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MIRA R35: Fibrin(ogen) in regulating health and disease - PROJECT SUMMARY/ABSTRACT Fibrin(ogen) plays a critical role in processes such as wound healing, coagulation, cancer, pregnancy, and inflammation. Fibrin(ogen), which is a blood plasma protein, forms a hierarchical network that gives rise to its unique mechanical and enzymatic stability. There is a need to understand the interplay between changes in the biochemical microenvironment that lead to the resulting fibrin network structure and its mechanical properties. We seek to apply engineering and biophysical techniques to address these fundamental questions. The long-term goal of the laboratory is to delineate the role that the structure- function relationship of fibrin(ogen) plays in regulating health and disease. To do this we will characterize the relationship of fibrin network structure with viscoelastic and rupture mechanics. Then, we will assess the rupture resistance of fibrin-collagen composites. We will determine how these two materials behave mechanically both together and at their interface to better understand the regulation of wound healing. We will study kinetics and the enzymatic dissolution of fibrin networks, where we will probe the influence of medications on stability. These fundamental studies have important translational and diagnostic implications going forward.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $387,370 )
2025	2025	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Biomedical Research and Research Training	000	2	6/2/2025	NON-COMPETING CONTINUATION	$387,370
														Subtotal = $387,370

Issue Date FY: 2024 ( Subtotal = $385,660 )
2024	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Biomedical Research and Research Training	000	1	7/23/2024	NEW	$385,660
														Subtotal = $385,660

Grand Total All Awards = $773,030

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MIRA R35: Fibrin(ogen) in regulating health and disease

Award Number: R35GM155242

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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