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Engineering Cell-Substrate Interactions on Porous Membranes to Create Physiologically Relevant Model Systems

Award Number: R35GM153461
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Engineering Cell-Substrate Interactions on Porous Membranes to Create Physiologically Relevant Model Systems - Abstract A significant shift is underway in many fields of biomedical research that are rapidly adopting microphysiological systems, also known as tissue chips. Microphysiological systems are being used by biomedical scientists for drug and toxicity testing, disease modeling, and to answer fundamental questions about cell-cell interactions in complex, but tightly controlled environments that can be parallelized for high throughput studies, often with high-resolution microscopy and other real-time readouts. In some studies, induced pluripotent stem cells (iPSCs) allow patient-specific models of drug testing, offering physiological relevance that cannot be matched by any animal model. A central component of nearly all microphysiological systems is the semi-permeable synthetic membrane that facilities co-culture or establishment of a tissue barrier model. This membrane serves to compartmentalize cells or microenvironments while also selectively allowing some species and even cells to transit or transmigrate, typically based simply on a pore size cut-off. While pore size is important for controlling communication between compartments or opposing sides of a barrier model, the membrane also serves as a support scaffold and culture substrate of nearly all cells involved in the system. The overall vision of this MIRA research program is to answer key questions in two interrelated domains: Improve the Understanding of Biological Mechanisms of Cell-Substrate Interactions on Porous Materials, and Advance Ultrathin Membrane Development and Engineer the Ideal Membrane for Physiologically Relevant Tissue Barrier and Co-Culture Models. For the next five years, this research program is focused on building upon my laboratory’s expertise in cell-substrate interactions and materials engineering, and evolving from biophysically focused analysis to understanding the molecular and signaling pathways that are likely driving cellular behaviors with the goal of engineering advanced membranes for more physiologically relevant tissue barrier models. Additionally, my laboratory seeks to move toward an understanding of the dynamics and equilibrium of cell-substrate interactions, particularly in the context of the transition between healthy and disease states in these microphysiological systems.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $362,320 )
2025	2025	ROCHESTER INSTITUTE OF TECHNOLOGY	1 LOMB MEMORIAL DR	ROCHESTER	NY	14623	MONROE	USA	Biomedical Research and Research Training	001	2	5/22/2025	NON-COMPETING CONTINUATION	$362,320
2025	2024	ROCHESTER INSTITUTE OF TECHNOLOGY	1 LOMB MEMORIAL DR	ROCHESTER	NY	14623	MONROE	USA	Biomedical Research and Research Training	000	1	11/5/2024	NEW	$0
														Subtotal = $362,320

Issue Date FY: 2024 ( Subtotal = $362,320 )
2024	2024	ROCHESTER INSTITUTE OF TECHNOLOGY	1 LOMB MEMORIAL DR	ROCHESTER	NY	14623	MONROE	USA	Biomedical Research and Research Training	000	1	5/7/2024	NEW	$362,320
														Subtotal = $362,320

Grand Total All Awards = $724,640

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Engineering Cell-Substrate Interactions on Porous Membranes to Create Physiologically Relevant Model Systems

Award Number: R35GM153461

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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