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Expanding the Chemical and Functional Space with Boron-Nitrogen Heterocycles

Award Number: R35GM153328
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Expanding the Chemical and Functional Space with Boron-Nitrogen Heterocycles - Project Summary/Abstract The generation of chemical space and its translation into new functions is one of the main goals of synthetic chemistry. The BN/CC isosterism (i.e., replacement of a carbon-carbon bond with a boron-nitrogen bond) has emerged as a viable strategy to increase the chemical space of compounds relevant to biomedical research. We seek to develop enabling tools that are provided by the new expanded chemical space through BN/CC isosterism of arenes: a) In the field of synthetic organic chemistry, we aim to 1) explore novel reactivity and selectivity that are unattainable by using “conventional” non-boron-containing organic compounds, and 2) discover and exploit new mechanistic principles for synthesis/catalysis, both as a consequence of the unique electronic structure created by BN heterocycles. When addressed, synthetic chemists will enjoy · new ligands that support metal-catalyzed reactions with distinct reactivity/selectivity, and · a versatile 4C+1N+1B synthon for synthesis. b) In the field of chemical biology, we aim to utilize BN-indole and its corresponding amino acid BN- tryptophan to 1) create novel BN-alloproteins in both bacterial and mammalian cells, 2) develop a novel bioconjugation platform that is rapid, catalyst-free, chemoselective, and orthogonal to existing bioconjugation methods, 3) develop a novel isosteric intrinsic fluorophore for characterizing protein interactions. Completion of the proposed aims will yield new fundamental knowledge related to boron in the context of synthetic organic and biological chemistry. It will generate new synthetic methods and research tools for the investigation of biological processes and inspire the design and development of new boron-containing molecules for biomedical applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $387,500 )
2025	2025	TRUSTEES OF BOSTON COLLEGE	140 COMMONWEALTH AVE	CHESTNUT HILL	MA	02467	MIDDLESEX	USA	Biomedical Research and Research Training	001	2	7/28/2025	NON-COMPETING CONTINUATION	$387,500
2025	2024	TRUSTEES OF BOSTON COLLEGE	140 COMMONWEALTH AVE	CHESTNUT HILL	MA	02467	MIDDLESEX	USA	Biomedical Research and Research Training	000	1	11/5/2024	NEW	$0
														Subtotal = $387,500

Issue Date FY: 2024 ( Subtotal = $387,500 )
2024	2024	TRUSTEES OF BOSTON COLLEGE	140 COMMONWEALTH AVE	CHESTNUT HILL	MA	02467	MIDDLESEX	USA	Biomedical Research and Research Training	000	1	9/9/2024	NEW	$387,500
														Subtotal = $387,500

Grand Total All Awards = $775,000

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Expanding the Chemical and Functional Space with Boron-Nitrogen Heterocycles

Award Number: R35GM153328

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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