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Mechanisms of vesicle trafficking and kinesin regulation

Award Number: R35GM153259
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Mechanisms of vesicle trafficking and kinesin regulation - PROJECT SUMMARY Nearly every aspect of cellular function—from development to metabolism and signaling—requires that membrane proteins be targeted to the correct location in the cell. This process requires high specificity as different cargoes are destined for different destinations. Although the basic steps of this process are known (i.e., cargoes are sorted into vesicles, the proper kinesins are recruited, and kinesins then transport vesicles to the proper destination), our current understanding of the mechanisms by which kinesins are recruited to vesicles and how their action is regulated on vesicles in live cells is extremely limited. Previously, the field lacked many of the tools needed to better characterize and understand these mechanisms, but our group has developed several cutting-edge tools that allow us for the first time to answer several fundamentally important questions. In this project, we will apply our experience with these tools in combination with primary hippocampal neuron culture and live cell imaging to achieve four key goals: 1) determine the mechanisms of on-vesicle regulation for kinesin- mediated transport, using Kinesin-3 family member KIF13A as an initial model, 2) identify molecular links between cargo sorting and kinesin recruitment, 3) determine the mechanisms that underlie the sorting of polarized cargoes at the trans-Golgi network, and 4) develop additional molecular tools in pursuit of these goals that also have applicability to the broader trafficking community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $398,909 )
2025	2025	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Biomedical Research and Research Training	001	2	5/23/2025	NON-COMPETING CONTINUATION	$398,909
2025	2024	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Biomedical Research and Research Training	000	1	11/6/2024	NEW	$0
														Subtotal = $398,909

Issue Date FY: 2024 ( Subtotal = $398,023 )
2024	2024	RENSSELAER POLYTECHNIC INSTITUTE	110 8TH ST	TROY	NY	12180	RENSSELAER	USA	Biomedical Research and Research Training	000	1	6/21/2024	NEW	$398,023
														Subtotal = $398,023

Grand Total All Awards = $796,932

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Mechanisms of vesicle trafficking and kinesin regulation

Award Number: R35GM153259

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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