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Molecular determinants of bacterial interactions and maintenance in the Vibrio fischeri-Euprymna scolopes symbiosis

Award Number: R35GM152259
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Molecular determinants of bacterial interactions and maintenance in the Vibrio fischeri-Euprymna scolopes symbiosis - PROJECT SUMMARY The health of animals often depends on their ability to form symbioses with bacteria that are acquired from environmental reservoirs. Bacteria that express specific traits that increase host fitness, and in many cases, hosts that lack these beneficial symbionts are at increased risk for developing disease. As part of our long- term goal to understand how these symbioses are established and maintained, this proposal will investigate several factors that impact the ability of the beneficial symbiont Vibrio fischeri to colonize and be maintained by its natural host the Hawaiian bobtail squid Euprymna scolopes. The focus will be on three areas: 1) interference competition among beneficial symbionts, 2) the role of sulfur metabolism in symbiont physiology, and 3) evolution of signaling systems in bacterial symbionts. Progress in understanding these areas will provide new insights into the mechanisms enabling bacterial symbionts to colonize and be maintained by their hosts. The findings associated with this project may contribute to the strategies employed to improve host health by manipulating beneficial symbionts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $353,543 )
2026	2026	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	3	12/15/2025	NON-COMPETING CONTINUATION	$353,543
														Subtotal = $353,543

Issue Date FY: 2025 ( Subtotal = $393,246 )
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	002	2	8/13/2025	NON-COMPETING CONTINUATION	$39,325
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	2	11/27/2024	NON-COMPETING CONTINUATION	$353,921
2025	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	1	11/5/2024	NEW	$0
														Subtotal = $393,246

Issue Date FY: 2024 ( Subtotal = $496,006 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	001	1	5/10/2024	SUPPLEMENT FOR EXPANSION	$88,780
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	1	2/1/2024	NEW	$407,226
														Subtotal = $496,006

Grand Total All Awards = $1,242,795

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Molecular determinants of bacterial interactions and maintenance in the Vibrio fischeri-Euprymna scolopes symbiosis

Award Number: R35GM152259

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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