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Post-transcriptional mRNA regulation in the mammalian nervous system

Award Number: R35GM152208
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Post-transcriptional mRNA regulation in the mammalian nervous system - The overall goal of research in my lab is to deepen our understanding of the roles of post-transcriptional gene regulation in the mammalian nervous system and how its dysregulation underlies human disease. In the next five years, we will build upon our previous work on neuronal mRNA metabolism and translation control and focus on three interconnected areas: 1} The impact of microsatellite repeat expansion on mRNA processing and translation. We will conduct targeted and genome-wide analyses to systematically identify the cis-elements and trans-factors that modulate noncanonical processing and translation of repeat-containing RNAs. 2} The functions and regulation of alternative translation initiation. Through our in-depth investigation of a conserved bi-functional mRNA that encodes two proteoforms of the neuronal pentraxin receptor (NPR}, we hope to uncover general principles that will inform our understanding of the regulatory impact of alternative start codon usage. 3} Quantitative measurement of mRNA translation efficiency (TE}. While ribosome footprint profiling, or Ribo-seq, is widely used to measure TE at a transcriptome scale, our recent findings suggest that conventional Ribo-seq procedures may not accurately capture the magnitude of TE regulation. By comparing Ribo-seq to directly measure TE data and optimizing Ribo-seq procedures, we will reexamine fundamental questions about translation control in mammalian cells. Results from these analyses may challenge existing dogmas and open up new lines of investigations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $482,400 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	001	2	11/19/2024	NON-COMPETING CONTINUATION	$434,160
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	002	2	8/13/2025	NON-COMPETING CONTINUATION	$48,240
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	1	11/5/2024	NEW	$0
														Subtotal = $482,400

Issue Date FY: 2024 ( Subtotal = $494,400 )
2024	2024	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	1	12/14/2023	NEW	$494,400
														Subtotal = $494,400

Grand Total All Awards = $976,800

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Post-transcriptional mRNA regulation in the mammalian nervous system

Award Number: R35GM152208

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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