Tuesday, July 1, 2025 7/1/2025

Nanoelectronics to study exosome circuitry and their role in neuroregeneration

Award Number: R35GM150860
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 05/31/2028

Group Awards By:

View Award Description

Nanoelectronics to study exosome circuitry and their role in neuroregeneration - Project Summary One of the important signaling networks in embryonic development, regeneration, and homeostasis of tissue is the endogenous bioelectricity. It has been observed that electric fields can promote axonal regrowth in nerve injury and bioelectric stimuli can be crucial to induce regeneration in peripheral and central nervous systems. However, the transduction mechanisms that allow cells to convert bioelectric signals into gene regulatory networks and transmit them to recipient cells via exocytosis pathways has not been fully understood. The overarching goals of this MIRA application for the next five years will be to understand the effect of endogenous electric fields on exocytosis pathway through the small extracellular vesicles (EVs); and to use this knowledge in the future to establish a new EV-based therapeutic to restore function and repair of neurons in neurological disorders and injuries. To address the knowledge gaps, we aim to first electrically stimulate Schwann cells (SCs), the glial component of peripheral nervous system, by developing a biomimetic piezoelectric nanofiber networks to mimic the endogenous bioelectric stimuli. The proposed bioactive piezoelectric nanofibers will be advantageous over current technologies since they have high spatial resolution and high surface to volume ratio that can promote cells attachment and alignment. Also, the piezoelectric properties of fibers allow cells to self- induce electrical stimulation as a result of mechanobiology which can better mimic the endogenous mechanotransduction feedback loop between cellular networks in a three-dimensional (3D) microenvironment. We further plan to investigate the role of EVs secreted from electrically stimulated SCs, as cargos to transmit the bioelectric signals by means of RNAs and proteins to neurons and to study their functional role in promoting the axonal regeneration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $401,095 )
2025	2025	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Biomedical Research and Research Training	000	3	5/20/2025	NON-COMPETING CONTINUATION	$401,095
														Subtotal = $401,095

Issue Date FY: 2024 ( Subtotal = $401,172 )
2024	2024	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Biomedical Research and Research Training	000	2	5/1/2024	NON-COMPETING CONTINUATION	$401,172
														Subtotal = $401,172

Issue Date FY: 2023 ( Subtotal = $401,247 )
2023	2023	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Biomedical Research and Research Training	000	1	7/17/2023	NEW	$401,247
														Subtotal = $401,247

Grand Total All Awards = $1,203,514

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Nanoelectronics to study exosome circuitry and their role in neuroregeneration

Award Number: R35GM150860

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 05/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer