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Macrophage-mediated regulation of inflammation and tissue repair

Award Number: R35GM150816
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Macrophage-mediated regulation of inflammation and tissue repair - PROJECT SUMMARY Inflammation is required for both pathogen clearance and tissue repair. Mucosal tissues are in continuous contact with the external environment, making these sites highly vulnerable to infection and tissue damage from a variety of sources. Damage can occur as a result of both external insults and the ensuing inflammatory cascade. Therefore, robust responses are required to both dampen inflammation and repair damaged tissue. Epithelial repair is known to occur through local stem and progenitor populations, however, the interplay between the epithelium and immune cells within the local microenvironment is more enigmatic. One such cell type, the macrophage, plays important roles in immune surveillance, repair, and homeostasis across multiple tissues. However, the direct role of macrophages in epithelial regeneration is not well understood. In my laboratory over the next several years, we will interrogate the role of macrophages in regulating inflammatory responses and promoting tissue repair and remodeling. More specifically, we are interested in deciphering macrophage- epithelial cell interactions following viral and chemical damage in mucosal tissues to identify novel regulators of repair. We will use both in vivo damage models and ex vivo organoid systems to: 1) determine how macrophages regulate inflammatory responses to promote host survival and 2) define how macrophages mediate tissue repair through communication with epithelial cells. The long-term goal of my research program is to expand our knowledge surrounding immune cell functions in tissue repair and remodeling in barrier tissues. Our proposed interdisciplinary approaches at the interface between innate immunity and regenerative medicine will bring fresh insight to biological problems at the center of many complex diseases. Understanding the reparative capacity of immune cell populations will allow development of new therapeutic strategies to dampen pathological inflammatory responses, enhance repair following infection and injury, and decrease the pathological tissue remodeling associated with many disease states.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $558,476 )
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Biomedical Research and Research Training	002	3	8/22/2025	SUPPLEMENT FOR EXPANSION	$95,102
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Biomedical Research and Research Training	001	3	7/21/2025	NON-COMPETING CONTINUATION	$423,750
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Biomedical Research and Research Training	000	2	11/27/2024	SUPPLEMENT FOR EXPANSION	$39,624
														Subtotal = $558,476

Issue Date FY: 2024 ( Subtotal = $423,750 )
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Biomedical Research and Research Training	001	2	7/29/2024	NON-COMPETING CONTINUATION	$42,375
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Biomedical Research and Research Training	000	2	3/29/2024	NON-COMPETING CONTINUATION	$381,375
														Subtotal = $423,750

Issue Date FY: 2023 ( Subtotal = $423,750 )
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Biomedical Research and Research Training	000	1	6/26/2023	NEW	$423,750
														Subtotal = $423,750

Grand Total All Awards = $1,405,976

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Macrophage-mediated regulation of inflammation and tissue repair

Award Number: R35GM150816

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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