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Supplement to Mechanisms of cellular morphogenesis that coordinate signaling during tissue patterning

Award Number: R35GM150782
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Supplement to Mechanisms of cellular morphogenesis that coordinate signaling during tissue patterning - Project Summary The long-term goal of our research program is to understand and identify the mechanisms of cell shape dynamics that facilitate the emergence of tissue-wide patterns from local cell-cell communication events. The incorrect spatial and temporal induction of genes and cell behaviors by perturbed signaling can lead to catastrophic errors in development. Therefore, it is critical to understand how signaling mechanisms that take place at the level of a cell or adjacent cells are coordinated across larger tissue length scales to achieve robust patterns and support tissue homeostasis. Cytonemes, or signaling filopodia, are long actin-rich cellular protrusions that allow cells to physically interact with, and signal to, other cells at a distance. Cellular protrusions like cytonemes have been shown to play a role in many developmental processes, including spot and stripe patterning, limb patterning, stem cell niche maintenance, and neural plate patterning. Despite this, relatively little is known about the general mechanisms that regulate cytoneme-specific formation and behavior. We are interested in understanding how these protrusions are regulated both at the level of cytoskeletal mechanisms, and as an integrated part of the cell-wide and tissue-wide signaling states. To address this problem, we use the spot pattern of bristles on the dorsal thorax of the fruit fly Drosophila melanogaster as a model system. During bristle patterning, cytonemes extend from the basal surface of thoracic epithelial cells to facilitate long-range, Notch-mediated, lateral inhibition. Leveraging our strengths in Drosophila model systems genetics and quantitative live microscopy, over the next five years our goals include understanding how the formation of cytonemes are regulated, especially downstream of Notch-mediated lateral inhibition signaling. In parallel, we aim to understand how cytoneme activity contributes to cell and tissue heterogeneities that facilitate the timely formation of well-organized patterns. These studies will not only yield valuable cell biological knowledge about the specific regulation of cytonemes, but will also elucidate fundamental mechanisms that coordinate patterning across length scales.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$519,396 )
2025	2024	CLARKSON UNIVERSITY	8 CLARKSON AVE	POTSDAM	NY	13676	SAINT LAWRENCE	USA	Biomedical Research and Research Training	003	2	5/14/2025	NON-COMPETING CONTINUATION	-$1
2025	2024	CLARKSON UNIVERSITY	8 CLARKSON AVE	POTSDAM	NY	13676	SAINT LAWRENCE	USA	Biomedical Research and Research Training	004	1	5/14/2025	SUPPLEMENT FOR EXPANSION	-$250,000
2025	2024	CLARKSON UNIVERSITY	8 CLARKSON AVE	POTSDAM	NY	13676	SAINT LAWRENCE	USA	Biomedical Research and Research Training	000	2	5/2/2025	NON-COMPETING CONTINUATION	-$355,096
2025	2024	HOWARD UNIVERSITY	2400 6TH ST NW	WASHINGTON	DC	20059	DISTRICT OF COLUMBIA	USA	Biomedical Research and Research Training	001	3	5/7/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$318,124
2025	2023	CLARKSON UNIVERSITY	8 CLARKSON AVE	POTSDAM	NY	13676	SAINT LAWRENCE	USA	Biomedical Research and Research Training	002	1	5/14/2025	NEW	-$232,423
														Subtotal = -$519,396

Issue Date FY: 2024 ( Subtotal = $605,097 )
2024	2024	CLARKSON UNIVERSITY	8 CLARKSON AVE	POTSDAM	NY	13676	SAINT LAWRENCE	USA	Biomedical Research and Research Training	000	1	5/21/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2024	CLARKSON UNIVERSITY	8 CLARKSON AVE	POTSDAM	NY	13676	SAINT LAWRENCE	USA	Biomedical Research and Research Training	001	2	6/18/2024	NON-COMPETING CONTINUATION	$355,097
														Subtotal = $605,097

Issue Date FY: 2023 ( Subtotal = $350,810 )
2023	2023	CLARKSON UNIVERSITY	8 CLARKSON AVE	POTSDAM	NY	13676	SAINT LAWRENCE	USA	Biomedical Research and Research Training	000	1	8/9/2023	NEW	$350,810
														Subtotal = $350,810

Grand Total All Awards = $436,511

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Supplement to Mechanisms of cellular morphogenesis that coordinate signaling during tissue patterning

Award Number: R35GM150782

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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