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A novel framework for nanomedicine development

Award Number: R35GM150758
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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A novel framework for nanomedicine development - Project Summary Nanomedicine is a research field centered around applying materials in the nanoscale size range (i.e. nanoparticles) as therapeutics and diagnostics. However, a major challenge is the safe, efficient, and effective delivery of nanoparticles to biological systems, such as cells, tissues, and organs. In this project, we will introduce and explore a novel framework for nanomedicine development with the ultimate goal of efficiently delivering non- viral nanoparticles to cells and tissues for safe and effective applications. Our proposed research program has three main strands: (i) we will develop novel nanoparticles for the safe, efficient, and effective delivery of small molecules and nucleic acid payloads to skeletal muscle cells; (ii) we will develop novel methods for super- resolution bioimaging to study the mechanisms and kinetics of nanoparticle spatiotemporal transport in biological systems; (iii) we will quantify safety, efficiency, and effectiveness of nanoparticle in vivo delivery. Using this novel framework, our long-term scientific goal is to create a major breakthrough in nanomedicine by developing safer, more efficient, and more effective nanoparticles for the non-viral delivery of small molecule-based drugs and nucleic acid payloads to enable therapeutic applications in skeletal muscle disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $373,297 )
2025	2025	UNIVERSITY OF OKLAHOMA	660 PARRINGTON OVAL RM 301	NORMAN	OK	73019	CLEVELAND	USA	Biomedical Research and Research Training	000	3	7/18/2025	NON-COMPETING CONTINUATION	$373,297
														Subtotal = $373,297

Issue Date FY: 2024 ( Subtotal = $373,297 )
2024	2024	UNIVERSITY OF OKLAHOMA	660 PARRINGTON OVAL RM 301	NORMAN	OK	73019	CLEVELAND	USA	Biomedical Research and Research Training	000	2	7/25/2024	NON-COMPETING CONTINUATION	$373,297
														Subtotal = $373,297

Issue Date FY: 2023 ( Subtotal = $373,297 )
2023	2023	UNIVERSITY OF OKLAHOMA	660 PARRINGTON OVAL RM 301	NORMAN	OK	73019	CLEVELAND	USA	Biomedical Research and Research Training	000	1	7/31/2023	NEW	$373,297
														Subtotal = $373,297

Grand Total All Awards = $1,119,891

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A novel framework for nanomedicine development

Award Number: R35GM150758

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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