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Engineering Tissue Level Targeting of Biologic Drugs via Automated Interfacial Microneedle Pumps

Award Number: R35GM150689
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Engineering Tissue Level Targeting of Biologic Drugs via Automated Interfacial Microneedle Pumps - Project Summary/Abstract: Biologic drugs have transformed the treatments of a variety of diseases, including diabetes, cancer, and heart disease. However, their large size prevents them from easily diffusing into targeted tissues when administered orally or via subcutaneous injection. For example, gastrointestinal mucosal tissue, myocardial muscle tissue and solid tumor tissue are so densely packed that macromolecules can barely penetrate hundreds of micrometers into the tissue from an implanted drug depot or leaky blood vessel. This prevents drugs, such as cytokines that have been demonstrated to promote wound healing in models of myocardial infarction, from reaching the impacted tissue areas where they could provide therapeutic effects. Even though local administration of drugs is becoming increasingly necessary to provide therapeutic efficacy, no research or tools exist on understanding the flow of fluid into tissue. Instead, healthcare professionals inject drugs manually with varying flow rates and pressures, leading to inconsistent care and potentially devastating consequences. Delivering too much drug too quickly may dislodge cancer cells in a solid tumor, promoting their circulation and generation of additional metastases. It may also cause drug to leak out of the solid tumor, generating systemic uptake and off-target effects. Delivering too slowly, on the other hand, may generate a depot profile where the distance between the drug and the impacted tissue is greater than the length that the drug can readily diffuse. This proposal will focus on developing an injection system for healthcare professionals to perform standardized and automated internal tissue injections. Injecting at flow rates optimized to the mechanical and physiological properties of the tissue will allow for greater drug distributions while preventing the off-target side effects and tissue damage generated from overpowered injections. Success of this proposal will yield (1) a computational model capable of predicting drug distributions in heart and solid tumor tissue at various injection characteristics as well as (2) a clinically translatable injection system that optimizes and standardizes injections of wound healing drugs and immunotherapies into these tissues, respectively.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $393,500 )
2025	2025	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	3	7/17/2025	NON-COMPETING CONTINUATION	$393,500
														Subtotal = $393,500

Issue Date FY: 2024 ( Subtotal = $393,500 )
2024	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	001	2	7/5/2024	NON-COMPETING CONTINUATION	$393,500
2024	2023	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	1	3/14/2024	NEW	$0
														Subtotal = $393,500

Issue Date FY: 2023 ( Subtotal = $393,500 )
2023	2023	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	1	7/25/2023	NEW	$393,500
														Subtotal = $393,500

Grand Total All Awards = $1,180,500

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Engineering Tissue Level Targeting of Biologic Drugs via Automated Interfacial Microneedle Pumps

Award Number: R35GM150689

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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