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Development of Strategies for the Synthesis of Heterocycles

Award Number: R35GM149246
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Development of Strategies for the Synthesis of Heterocycles - Project Summary/Abstract Heterocycles are ubiquitous components of pharmaceutical drugs essential for human health. A particularly attractive approach to nitrogen containing heterocycles is the modification of cheap and readily available amines via C–H bond functionalization. However, methods that efficiently accomplish this task typically require the use of expensive transition metal catalysts and/or oxidants. This proposal is focused on the design and development of efficient and practical methods for amine functionalization, including the development of asymmetric variants. The main goal is the alpha- functionalization of amines through conceptually new and underdeveloped methods of substrate activation. Unique methods for the synthesis of heterocycles will also be explored in the context of asymmetric Lewis and BrØnsted acid catalysis. In addition to targeting the rapid preparation of compounds related to structures with known biological activities, efforts will center on the development of particularly powerful reactions that rapidly produce new polycyclic heterocycles. A priority is the generation of new structural frameworks that are absent from current drug discovery screening libraries.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $316,770 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	000	4	1/29/2026	NON-COMPETING CONTINUATION	$316,770
														Subtotal = $316,770

Issue Date FY: 2025 ( Subtotal = $357,345 )
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	001	3	4/10/2025	NON-COMPETING CONTINUATION	$357,345
2025	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	000	2	11/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $357,345

Issue Date FY: 2024 ( Subtotal = $358,483 )
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	001	2	5/21/2024	NON-COMPETING CONTINUATION	$35,848
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	000	2	2/1/2024	NON-COMPETING CONTINUATION	$322,635
														Subtotal = $358,483

Issue Date FY: 2023 ( Subtotal = $360,553 )
2023	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Biomedical Research and Research Training	000	1	4/14/2023	NEW	$360,553
														Subtotal = $360,553

Grand Total All Awards = $1,393,151

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Development of Strategies for the Synthesis of Heterocycles

Award Number: R35GM149246

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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