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Development of a Portable Ion Mobility Spectrometer For Efficient Diagnosis of Various Diseases

Award Number: R35GM147225
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Development of a Portable Ion Mobility Spectrometer For Efficient Diagnosis of Various Diseases - Development of a Portable Ion Mobility Spectrometer for Efficient Diagnosis of various diseases This research will focus on the identification of the biomarkers associated with various diseases and the development and validation of an innovative high-resolution ion mobility (IM) device. The proposed device is based on a new variant of Structures for Lossless Ion Manipulations (SLIM) and will couple high-resolution ion mobility separations achieved by traveling wave (TW)-SLIM with drift tube (DT)-SLIM which is a novel approach that can provide collision cross section (CCS) values of the separated isomers/conformers that are unique to the target biomarkers of interest. We expect this capability to increase biomarkers’ identification accuracy. In addition, by combining the attributes of the high-resolution ion mobility and ambient ionization, sensitive detection, and superior separation power will be achieved in the analysis of complex clinical samples without any prior sample preparation. The current diagnosis methods are often slow, expensive, or laborious which limits their use in resource-limited regions. Therefore, there is a strong unmet need for new technologies that can rapidly diagnose various diseases to complement the existing commercially available technologies. Rapid identification of diagnostic biomarkers in clinical samples will not only lead to an increase in recovery rates but also will lead to shorter hospitalization stays and reduced antibiotic resistance. We aim to develop a portable IM diagnostic device that can be used for the identification of the biomarkers associated with foodborne and Alzheimer’s diseases which significantly impact the lives of millions of people. The significance of these diseases causes diagnostic tests to play a major role in the clinical care of patients suffering from these diseases Our studies will enable high throughput analyses that are affordable and so easy-to-operate that can be performed by less-skilled users, such as nurses and their assistants. Over the long term, these studies will be extended to multiple applications that span from the fundamental studies of molecular structure elucidation to advanced analytical applications such as a widely usable point-of-care diagnostic device that can serve the community, especially resource-limited regions. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $373,958 )
2024	2024	AUBURN UNIVERSITY	321-A INGRAM HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	3	8/13/2024	NON-COMPETING CONTINUATION	$373,958
														Subtotal = $373,958

Issue Date FY: 2023 ( Subtotal = $374,062 )
2023	2023	AUBURN UNIVERSITY	321-A INGRAM HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	2	7/10/2023	NON-COMPETING CONTINUATION	$374,062
														Subtotal = $374,062

Issue Date FY: 2022 ( Subtotal = $284,912 )
2022	2022	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	1	9/21/2022	NEW	$284,912
														Subtotal = $284,912

Grand Total All Awards = $1,032,932

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Development of a Portable Ion Mobility Spectrometer For Efficient Diagnosis of Various Diseases

Award Number: R35GM147225

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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