Wednesday, October 15, 2025 10/15/2025

Ribosome Quality Control Mechanisms in Gram-positive Bacteria

Award Number: R35GM147049
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Ribosome Quality Control Mechanisms in Gram-positive Bacteria - Project Summary: Although bacterial ribosomes have been biochemically interrogated for decades, unknown mechanisms of regulation and quality control are regularly uncovered and targeted with new antibiotics. Major differences in translation regulation between Gram-positive and Gram-negative bacteria have come to light in recent years. Although more than 200,000 infections per year in the United States are caused by antibiotic resistant Gram- positive bacteria, major gaps remain in our understanding of how Gram-positives perform ribosome quality control. To address these gaps, my research program will focus on two major areas. 1) We will identify and characterize strategies used by Gram-positive bacteria to detect and rescue stalled ribosomes and investigate the physiological impacts of ribosome stalling. Preliminary data from my laboratory supports a model in which ribosome stalling in Bacillus subtilis and Bacillus anthracis results in frameshifting and premature translation termination. This process is expected to result in toxic truncated proteins and trigger stress responses. We will investigate this model using genetic, structural, and biochemical approaches. 2) We will determine how ribosome flexibility and atypical translation events can be used by the cell to increase coding capacity. We are particularly interested in how frameshifting and stop codon read-through regulates gene expression and how environmental inputs control this type of regulation. We will also use unbiased high throughput genetics to uncover new mechanisms that prevent stalling and that regulate programmed frameshifting and stop codon read-through.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $365,297 )
2025	2025	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	4	7/16/2025	NON-COMPETING CONTINUATION	$365,297
														Subtotal = $365,297

Issue Date FY: 2024 ( Subtotal = $366,153 )
2024	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	3	5/15/2024	NON-COMPETING CONTINUATION	$366,153
														Subtotal = $366,153

Issue Date FY: 2023 ( Subtotal = $406,711 )
2023	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	001	2	6/16/2023	SUPPLEMENT FOR EXPANSION	$39,779
2023	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	2	6/15/2023	NON-COMPETING CONTINUATION	$366,932
														Subtotal = $406,711

Issue Date FY: 2022 ( Subtotal = $367,640 )
2022	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	1	7/29/2022	NEW	$367,640
														Subtotal = $367,640

Grand Total All Awards = $1,505,801

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Ribosome Quality Control Mechanisms in Gram-positive Bacteria

Award Number: R35GM147049

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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