Thursday, January 8, 2026 1/8/2026

SYNTHETIC PHOTOCHEMISTRY

Award Number: R35GM144129
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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SYNTHETIC PHOTOCHEMISTRY - PROJECT SUMMARY/ABSTRACT Synthetic photochemistry is a powerful tool for biomedical research. The small-molecule therapeutics that constitute the core of modern molecular medicine occupy a relatively narrow segment of chemical diversity space. Photochemistry offers a new capability that can expand the range of chemical structures that can be investigated for their biological activity and their potential as new life-saving drugs. Specifically, reactions that are driven by light can use the energy of a photon to produce highly reactive intermediates that react in ways that are not accessible by other means. Our group's research focuses on the discovery of reaction methods that can control the outcomes of photochemical processes in predictable ways. We have a long-standing interest in the development of mechanistically novel catalytic processes that are directly applicable to the synthesis of complex bioactive compounds. We are also interested in the use of external stimuli that can control or divert the intrinsic reactivity of open-shelled photogenerated intermediates towards desirable synthetic goals. Finally, we are deeply committed to elucidating the mechanisms by which photochemical transformations occur. The next phase of our research will continue to investigate these broad themes. We propose investigations into new strategies for controlling the stereochemistry of diverse photochemical reactions. We will study a new approach towards the generation of carbocationic intermediates from photoredox activation. Finally, we will develop a new class of photoreactions that take advantage of the direct photochemistry of base metal coordination complexes. These studies will result in new, generalizable strategies for the controlled photochemical synthesis of complex organic molecules.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $518,715 )
2026	2026	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	5	12/15/2025	NON-COMPETING CONTINUATION	$518,715
														Subtotal = $518,715

Issue Date FY: 2025 ( Subtotal = $576,351 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	002	4	8/8/2025	NON-COMPETING CONTINUATION	$57,636
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	001	4	12/18/2024	NON-COMPETING CONTINUATION	$518,715
2025	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	3	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $576,351

Issue Date FY: 2024 ( Subtotal = $650,727 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	001	3	5/20/2024	NON-COMPETING CONTINUATION	$57,636
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	3	12/14/2023	NON-COMPETING CONTINUATION	$518,715
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	002	3	9/9/2024	SUPPLEMENT FOR EXPANSION	$74,376
														Subtotal = $650,727

Issue Date FY: 2023 ( Subtotal = $627,786 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	001	2	4/5/2023	NON-COMPETING CONTINUATION	$57,636
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	2	12/19/2022	NON-COMPETING CONTINUATION	$518,715
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	002	2	7/5/2023	SUPPLEMENT FOR EXPANSION	$51,435
														Subtotal = $627,786

Issue Date FY: 2022 ( Subtotal = $222,711 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Biomedical Research and Research Training	000	1	12/22/2021	NEW	$222,711
														Subtotal = $222,711

Grand Total All Awards = $2,596,290

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SYNTHETIC PHOTOCHEMISTRY

Award Number: R35GM144129

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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