Thursday, November 21, 2024 11/21/2024

Uncover Spatial-Constraint Related Morphome Using Tissue-on-a-Chip Platform and Data-Driven Mathematical Modeling

Award Number: R35GM143194
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Cell behaviors and tissue developments often occur under spatial constraints (e.g., interstitial space, tissue lining, skull enclosure). The current in vitro systems are often open cultures, and thus miss the spatial constraints and other in vivo stimuli. The current in vivo models are often low throughput and hard-to-trace, therefore unable to unravel the complex interplay between intrinsic influences (e.g., genetics/epigenetics) and extrinsic ones (e.g., micro-environment). For example, cell membrane blebbing and brain folding are fundamental and impactful bio-behaviors under spatial constraints. Their biophysical and molecular mechanisms are not well understood. Lately, several experimental and theoretical tools have emerged to fascinate the modeling of complex bio-behaviors. This proposed study aims to parameterize morphological information, relate to the complex influences under spatial constraints, and unravel the mechanism of bio- behaviors in the two exemplified areas. It will be done through a morphome platform that integrates several experimental-theoretical tools (e.g., tissue-on-a-chip, data-driven modeling, machine-learning), which has been pre-defined by PI and Co-Is. We hope to 1) fill the compelling gaps in our understanding of membrane blebbing and brain folding process and 2) establish an effective strategy to uncover a broad range of basic biological processes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $356,267 )
2024	2024	UTAH STATE UNIVERSITY	1000 OLD MAIN HL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	4	9/17/2024	NON-COMPETING CONTINUATION	$356,267
														Subtotal = $356,267

Issue Date FY: 2023 ( Subtotal = $356,683 )
2023	2023	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	3	9/19/2023	NON-COMPETING CONTINUATION	$356,683
														Subtotal = $356,683

Issue Date FY: 2022 ( Subtotal = $605,653 )
2022	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	8/9/2022	SUPPLEMENT FOR EXPANSION	$248,574
2022	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	001	2	8/26/2022	NON-COMPETING CONTINUATION	$357,079
														Subtotal = $605,653

Issue Date FY: 2021 ( Subtotal = $258,012 )
2021	2021	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	8/31/2021	NEW	$258,012
														Subtotal = $258,012

Grand Total All Awards = $1,576,615

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Uncover Spatial-Constraint Related Morphome Using Tissue-on-a-Chip Platform and Data-Driven Mathematical Modeling

Award Number: R35GM143194

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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