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Administrative supplement to purchase a MerMade 4 oligonucleotide synthesizer for the large-scale production of modified RNA substrates

Award Number: R35GM143000
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT: Our NIH R35 ESI MIRA entitled ‘Selectivity and regulation of mRNA demethylation by iron- dependent dioxygenases’ focuses on understanding the structural and molecular determinants of AlkBH-family RNA demethylase enzymes that play key roles in RNA function and some human cancers. A critical challenge to carrying out some of the proposed structural experiments has been in obtaining sufficient quantities of modified RNA oligonucleotide substrates for crystallographic screening and biophysical binding assays. This administrative supplement requests funds to purchase an LGC MerMade 4 oligonucleotide synthesizer that will transform and greatly accelerate our ability to access key modified RNA oligonucleotide reagents to support multiple goals of our MIRA projects.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $486,374 )
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	3	4/28/2023	NON-COMPETING CONTINUATION	$391,301
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	3	6/22/2023	SUPPLEMENT FOR EXPANSION	$95,073
														Subtotal = $486,374

Issue Date FY: 2022 ( Subtotal = $391,554 )
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	2	5/11/2022	NON-COMPETING CONTINUATION	$391,554
														Subtotal = $391,554

Issue Date FY: 2021 ( Subtotal = $391,800 )
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	1	6/25/2021	NEW	$391,800
														Subtotal = $391,800

Grand Total All Awards = $1,269,728

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Administrative supplement to purchase a MerMade 4 oligonucleotide synthesizer for the large-scale production of modified RNA substrates

Award Number: R35GM143000

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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