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Evolutionary Genetics of Animal Development

Award Number: R35GM141906
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2030

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Evolutionary Genetics of Animal Development - PROJECT SUMMARY Genes play two different roles in biology, giving shape to phenotypes through developmental processes within individuals, and transmitting traits across generations through Mendelian inheritance. Evolutionary developmental geneticists work at the intersection of these roles, asking how the mechanisms that operate within individuals influence the origin, maintenance, and fate of phenotypic variation in populations. Gametogenesis and early embryonic development bridge the divide between individual and population. Development involves molecular and cellular contributions from the embryo's own zygotic genome but also from the substance of the egg and the sperm, products gametogenesis shaped by the parents’ genomes. This simultaneous regulation by multiple genomes creates distinctive inheritance properties that alter predictions about patterns of variation and divergence. To better understand how parental and zygotic genetic effects and their interactions shape variation and evolution, this project sets as its goal the characterization of genetic architectures of generation-spanning phenotypes in multiple experimental model systems, each with unique complementary features. One line of research focuses on variation in development and life history in an annelid model system, Streblospio benedicti. This species is unique in exhibiting both direct and indirect development as heritable variation, with the alternative modes representing adaptive strategies to different environmental conditions. Our population-genomic data have pinpointed tens of loci associated with the difference between two dramatically different modes of development and life-history patterns, and experimental crosses to isolate the effects of these loci allow precise reconstruction of the sequence of parental- and zygotic-effect genetic changes underlying a major evolutionary transition. These data will guide construction of improved population genetic models incorporating parental-zygotic genetic interactions. The second line of research focuses on Caenorhabditis nematodes, a longstanding experimental model for genetics. These animals exhibit sex-ratio bias and sex-associated inheritance of autosomes, both features dependent on non-Mendelian assortment during male gametogenesis. Building on the lab's extensive resources for quantitative genetic analysis in these animals, we will discover the genetic basis for variation in these traits and test hypotheses about genetic conflict between parents in the regulation of offspring sex. Regulation of chromosomal and cytoplasmic transmission, and genetic interactions between chromosomal and cytoplasmic factors, are widely shared across animals and insights from model organisms are expected to generalize to conditions of human health and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $440,178 )
2026	2026	NEW YORK UNIVERSITY	70 WASHINGTON SQ S FL 11	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	6	4/29/2026	COMPETING CONTINUATION	$440,178
														Subtotal = $440,178

Issue Date FY: 2025 ( Subtotal = $396,250 )
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	002	5	8/5/2025	NON-COMPETING CONTINUATION	$39,625
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	5	3/21/2025	NON-COMPETING CONTINUATION	$356,625
2025	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	4	11/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $396,250

Issue Date FY: 2024 ( Subtotal = $627,635 )
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	4	6/6/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	002	4	7/23/2024	NON-COMPETING CONTINUATION	$37,763
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	4	3/18/2024	NON-COMPETING CONTINUATION	$339,872
														Subtotal = $627,635

Issue Date FY: 2023 ( Subtotal = $379,497 )
2023	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	3	3/16/2023	NON-COMPETING CONTINUATION	$379,497
														Subtotal = $379,497

Issue Date FY: 2022 ( Subtotal = $370,189 )
2022	2022	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	2	3/18/2022	NON-COMPETING CONTINUATION	$333,170
2022	2022	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	2	7/21/2022	NON-COMPETING CONTINUATION	$37,019
														Subtotal = $370,189

Issue Date FY: 2021 ( Subtotal = $373,912 )
2021	2021	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	1	3/12/2021	NEW	$373,912
														Subtotal = $373,912

Grand Total All Awards = $2,587,661

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Evolutionary Genetics of Animal Development

Award Number: R35GM141906

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2030

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