Thursday, November 21, 2024 11/21/2024

Identification and study of adaptive mutations and phenotypes using laboratory growth of C. elegans

Award Number: R35GM139594
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Evolutionary forces have important consequences for human diseases of development, social behavior, and metabolism along with the progression of cancers and susceptibility to pathogens. These forces largely determine the types of genetic changes and genes that influence or underlie these traits. The goal of the McGrath lab is to understand the genetic basis of adaptation. What are the genetic changes that can increase fitness and how do they modify cellular activity and phenotypic change to accomplish this? Experimental evolution using the model organism C. elegans is a powerful approach to address these questions. C. elegans, a genetically-tractable, short-lived nematode, can be used to study the evolution of development, behavior, and sexual reproduction. In the next five years, the McGrath lab will identify continue to identify the genetic, cellular, and phenotypic basis of adaptation, focusing on three main areas. First, the genetic and cellular basis of pheromone-dependent trait evolution will be characterized. C. elegans release and sense dozens of acaroside pheromones that modify a large number of behavioral and developmental traits. This work will provide a model for understanding how neural circuits evolve to modify pheromone signaling in new environments. Second, the functional evolution of the NURF chromatin remodeling complex will be characterized in a number of nematode species. Chromatin state regulates gene expression; it is important for determining cell fate and phenotypic plasticity. Genetic mutations in chromatin remodelers are an important risk factor for many cancers. Finally, genes and neurons responsible for differences in food consumption will be identified. Obesity is a common risk factor in Americans. Fundamental work in C. elegans could help us design approaches to decrease obesity in humans. In total, this work will provide a view of adaptation in a multicellular organism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	4	11/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $395,500 )
2024	2024	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	4	12/19/2023	NON-COMPETING CONTINUATION	$355,950
2024	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	001	4	7/9/2024	NON-COMPETING CONTINUATION	$39,550
														Subtotal = $395,500

Issue Date FY: 2023 ( Subtotal = $395,500 )
2023	2023	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	3	1/4/2023	NON-COMPETING CONTINUATION	$355,950
2023	2023	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	001	3	3/24/2023	NON-COMPETING CONTINUATION	$39,550
														Subtotal = $395,500

Issue Date FY: 2022 ( Subtotal = $395,500 )
2022	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	2	12/27/2021	NON-COMPETING CONTINUATION	$355,950
2022	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	001	2	7/20/2022	NON-COMPETING CONTINUATION	$39,550
														Subtotal = $395,500

Issue Date FY: 2021 ( Subtotal = $395,500 )
2021	2021	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	1	2/23/2021	NEW	$395,500
														Subtotal = $395,500

Grand Total All Awards = $1,582,000

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Identification and study of adaptive mutations and phenotypes using laboratory growth of C. elegans

Award Number: R35GM139594

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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