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Function of Protein Methylation in Chromatin and Signaling Regulation

Award Number: R35GM139569
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2031

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Function of Protein Methylation in Chromatin and Signaling Regulation - ABSTRACT Covalent post-translational protein modifications (PTMs) contribute to all aspects of cell physiology and are a major source of protein functional diversity in mammalian cells. Aberrant regulation of PTMs is a common feature of human diseases. Our research focuses on an important PTM: protein methylation occurring on lysine residues as well as on less common residues. Our overarching goal is to elucidate at a molecular level the physiologic roles for protein methylation signaling in the regulation of chromatin biology, epigenetics, protein synthesis, and other fundamental biological processes, and to understand how disruption in these mechanisms contributes to human disease. Within this research framework we will investigate the biology and function of enzymes that regulate histone methylation dynamics, with a focus on methylation at histone H3 lysine 36 (H3K36). Beyond histone methylation, there is a growing appreciation that a number of non-histone proteins, including several with clear roles in gene expression and signal transduction are lysine methylated. Indeed, there are likely more than seventy-five lysine methyltransferases in the human genome, and an increasing number of examples of alterations in these genes being linked to human disorders. Thus, it is likely that non- histone protein methylation dynamics plays a crucial role in physiology and in disease pathogenesis. We will explore the biology and function of non-histone protein methylation signaling pathways. In addition to lysine methylation, other residues like histidine are also methylated, though relatively little is known about these methylation modification network. We will explore the hypothesis that non-canonical protein methylation has an underappreciated and significant role in signal transduction, cell biology, and disease. For our studies, we will use a multi-disciplinary strategy that include biochemical, molecular, proteomic, genomic, genetic, chemical, cellular and mouse modeling approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $712,349 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	002	6	2/26/2026	COMPETING CONTINUATION	$712,349
2026	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	5	1/23/2026	NON-COMPETING CONTINUATION	$0
2026	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	5	2/25/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $712,349

Issue Date FY: 2025 ( Subtotal = $667,363 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	5	2/20/2025	NON-COMPETING CONTINUATION	$600,628
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	002	5	8/12/2025	NON-COMPETING CONTINUATION	$66,735
2025	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	4	11/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $667,363

Issue Date FY: 2024 ( Subtotal = $667,363 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	4	1/31/2024	NON-COMPETING CONTINUATION	$600,628
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	4	6/21/2024	NON-COMPETING CONTINUATION	$66,735
														Subtotal = $667,363

Issue Date FY: 2023 ( Subtotal = $667,363 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	3	2/17/2023	NON-COMPETING CONTINUATION	$667,363
														Subtotal = $667,363

Issue Date FY: 2022 ( Subtotal = $667,363 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	2	2/28/2022	NON-COMPETING CONTINUATION	$600,626
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	2	7/14/2022	NON-COMPETING CONTINUATION	$66,737
														Subtotal = $667,363

Issue Date FY: 2021 ( Subtotal = $627,416 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	1	2/3/2021	NEW	$627,416
														Subtotal = $627,416

Grand Total All Awards = $4,009,217

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Function of Protein Methylation in Chromatin and Signaling Regulation

Award Number: R35GM139569

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2031

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