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Evolutionary genetics of genotype-by-environment interactions for complex traits

Award Number: R35GM138300
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Evolutionary genetics of genotype-by-environment interactions for complex traits - PROJECT SUMMARY A key question in my research is: why does diversity in quantitative traits persist, despite evidence of selection that should eliminate this diversity? Environmental variation can generate genetic tradeoffs both among and within populations, helping to maintain this genetic diversity. I study the genetic mechanisms and architecture of these tradeoffs in nature. My recent research has focused on two central goals: 1) developing approaches for finding the genetic basis of local adaptation and 2) empirical testing of hypotheses about local adaptation and G×E. I propose research to study genetic mechanisms of adaptation to environment using a model system that is convenient for ecological experimentation, Arabidopsis thaliana. This work will test hypotheses about the genetic architecture of adaptation to changing environments through space and time, about how gene flow influences genetic architecture, and about the role of gene expression plasticity in adaptation to variable environments. In all projects, our ability to conduct ecologically realistic but controlled common garden experiments will provide information on genetic variation in environmental responses (G×E) that can be used to interpret observational data from nature. We will first study the genetic mechanisms of adaptation to temporally changing environments. We will study how different populations of have adapted to hundreds of generations of environmental change by sequencing genomes of museum specimens. Second, we will study local adaptation along montane environmental gradients with different levels of isolation to test how gene flow influences the architecture of local adaptation. This project will collect populations from different geographic contexts and conduct experiments to characterize the genetic basis of local adaptation and expression plasticity. My proposed work will make important strides in testing how tradeoffs along complex environmental gradients influence genetic diversity across the genome.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $336,144 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	5	5/9/2024	NON-COMPETING CONTINUATION	$336,144
														Subtotal = $336,144

Issue Date FY: 2023 ( Subtotal = $365,019 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	4	5/22/2023	NON-COMPETING CONTINUATION	$365,019
														Subtotal = $365,019

Issue Date FY: 2022 ( Subtotal = $365,235 )
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	3	5/30/2022	NON-COMPETING CONTINUATION	$365,235
														Subtotal = $365,235

Issue Date FY: 2021 ( Subtotal = $371,105 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	2	5/18/2021	NON-COMPETING CONTINUATION	$371,105
														Subtotal = $371,105

Issue Date FY: 2020 ( Subtotal = $371,105 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	1	7/31/2020	NEW	$371,105
														Subtotal = $371,105

Grand Total All Awards = $1,808,608

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Evolutionary genetics of genotype-by-environment interactions for complex traits

Award Number: R35GM138300

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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