Tuesday, August 19, 2025 8/19/2025

MECHANISMS OF CONTRACTILE NETWORK ASSEMBLY

Award Number: R35GM138183
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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MECHANISMS OF CONTRACTILE NETWORK ASSEMBLY - Project Summary/Abstract A fundamental question in cell physiology is how appropriate levels of cell contractility are generated to drive cell and tissue morphogenesis and mechanical homeostasis. We know cells contractile events to enable dynamic movements. We do not know how they generate and tune contractility in the right place at the right time. Myosin 2 filaments are the dominant force- generating motor proteins in all cells and tissues. This proposal uses an array of molecular, cellular, and imaging techniques to understand myosin 2 modulation and function in living mammalian cells. We anticipate the completion of this work will answer critical questions and yield important new avenues to pursue.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $428,666 )
2025	2025	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Biomedical Research and Research Training	000	6	7/18/2025	COMPETING CONTINUATION	$428,666
														Subtotal = $428,666

Issue Date FY: 2024 ( Subtotal = $369,351 )
2024	2024	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Biomedical Research and Research Training	000	5	8/6/2024	NON-COMPETING CONTINUATION	$369,351
														Subtotal = $369,351

Issue Date FY: 2023 ( Subtotal = $473,611 )
2023	2023	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Biomedical Research and Research Training	000	4	8/4/2023	NON-COMPETING CONTINUATION	$369,351
2023	2023	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Biomedical Research and Research Training	001	4	9/15/2023	SUPPLEMENT FOR EXPANSION	$104,260
														Subtotal = $473,611

Issue Date FY: 2022 ( Subtotal = $369,351 )
2022	2022	LOYOLA UNIVERSITY OF CHICAGO	2160 S 1ST AVE	MAYWOOD	IL	60153	COOK	USA	Biomedical Research and Research Training	000	3	8/9/2022	NON-COMPETING CONTINUATION	$369,351
														Subtotal = $369,351

Issue Date FY: 2021 ( Subtotal = $369,351 )
2021	2021	LOYOLA UNIVERSITY OF CHICAGO	2160 S FIRST AVE	MAYWOOD	IL	60153	COOK	USA	Biomedical Research and Research Training	000	2	8/17/2021	NON-COMPETING CONTINUATION	$369,351
														Subtotal = $369,351

Issue Date FY: 2020 ( Subtotal = $368,430 )
2020	2020	LOYOLA UNIVERSITY OF CHICAGO	2160 S FIRST AVE	MAYWOOD	IL	60153	COOK	USA	Biomedical Research and Research Training	000	1	8/19/2020	NEW	$368,430
														Subtotal = $368,430

Grand Total All Awards = $2,378,760

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MECHANISMS OF CONTRACTILE NETWORK ASSEMBLY

Award Number: R35GM138183

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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