Wednesday, January 15, 2025 1/15/2025

Improving Small Molecule Synthesis by Controlling Reactions between Transition Metals and Carbon-Heteroatom Electrophiles

Award Number: R35GM137971
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Transition metal-catalyzed cross coupling reactions are among the most widely used strategies for C—C and C—N bond formation during the synthesis of small molecules for biomedical research. Despite their widespread use, limitations to these methods can often be attributed to poor control over the metal's reactivity or selectivity during key elementary steps of the catalytic cycle. In particular, problems with oxidative addition can limit the chemical space that can be accessed through cross coupling methods. During this elementary step, a transition metal oxidatively inserts into a bond of an electrophile (typically a carbon–heteroatom bond). Challenges related to this step include (1) subverting conventional site selectivity when two or more identical halides are present on aromatic substrates, (2) exploiting relatively non-labile phenol derivatives as electrophilic coupling partners, and (3) developing selective, mild cross-coupling reactions catalyzed by low-toxicity base metals such as iron and cobalt. This proposal seeks to develop solutions to these challenges through a combined experimental and computational approach. Completion of this work will help to streamline access to pharmacologically relevant compounds through more efficient catalytic methods. Furthermore, an in-depth understanding of the mechanistic origin of selectivity and reactivity in these systems will lay the groundwork for future rational design of new catalytic systems.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $343,279 )
2024	2024	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Biomedical Research and Research Training	000	5	6/28/2024	NON-COMPETING CONTINUATION	$343,279
														Subtotal = $343,279

Issue Date FY: 2023 ( Subtotal = $431,581 )
2023	2023	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Biomedical Research and Research Training	000	4	6/5/2023	NON-COMPETING CONTINUATION	$343,279
2023	2023	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Biomedical Research and Research Training	001	4	6/27/2023	SUPPLEMENT FOR EXPANSION	$88,302
														Subtotal = $431,581

Issue Date FY: 2022 ( Subtotal = $343,279 )
2022	2022	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Biomedical Research and Research Training	000	3	6/16/2022	NON-COMPETING CONTINUATION	$343,279
														Subtotal = $343,279

Issue Date FY: 2021 ( Subtotal = $343,279 )
2021	2021	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Biomedical Research and Research Training	000	2	6/15/2021	NON-COMPETING CONTINUATION	$343,279
														Subtotal = $343,279

Issue Date FY: 2020 ( Subtotal = $343,279 )
2020	2020	MONTANA STATE UNIVERSITY, INC	211 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Biomedical Research and Research Training	000	1	8/6/2020	NEW	$343,279
														Subtotal = $343,279

Grand Total All Awards = $1,804,697

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Improving Small Molecule Synthesis by Controlling Reactions between Transition Metals and Carbon-Heteroatom Electrophiles

Award Number: R35GM137971

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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