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Mapping the Dynamic Interactome of Ig-fold Membrane Proteins Using Nanobody-Based Tools

Award Number: R35GM137905
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2031

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Mapping the Dynamic Interactome of Ig-fold Membrane Proteins Using Nanobody-Based Tools - PROJECT SUMMARY This project aims to develop a nanobody-based proximity proteomics platform to map the dynamic interactomes of immunoglobulin (Ig)-fold membrane proteins, which are crucial in cellular communication and signaling. By focusing on underexplored targets, we seek to uncover novel insights into their interaction networks and signaling pathways. Leveraging advanced nanobody engineering and photochemistry, our approach will enable high-resolution analysis of membrane protein interactions under physiological conditions. This research has the potential to identify new therapeutic targets and advance our understanding of membrane protein biology, with implications for treating diseases linked to these proteins, including cancer and neurodegenerative disorders. Nanobodies, derived from camelid single-domain antibodies, offer several advantages over traditional antibodies, including smaller size, higher stability, and the ability to access cryptic epitopes. These properties make them particularly suitable for studying membrane proteins in their native environments. By integrating nanobody technology with proximity labeling techniques, we aim to capture transient and low-abundance interactions that are often challenging to detect with conventional methods. This innovative approach will provide a comprehensive understanding of the spatial and temporal dynamics of Ig-fold membrane protein interactions, shedding light on their roles in health and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $462,000 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	001	6	2/13/2026	COMPETING CONTINUATION	$462,000
2026	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	000	5	2/13/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $462,000

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	000	5	8/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $422,500 )
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	000	5	8/19/2024	NON-COMPETING CONTINUATION	$422,500
														Subtotal = $422,500

Issue Date FY: 2023 ( Subtotal = $509,258 )
2023	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	002	4	8/23/2023	NON-COMPETING CONTINUATION	$422,500
2023	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	003	4	9/1/2023	SUPPLEMENT FOR EXPANSION	$86,758
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	001	3	3/23/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$251,349
2023	2021	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Biomedical Research and Research Training	000	2	3/23/2023	NON-COMPETING CONTINUATION	-$251,349
														Subtotal = $509,258

Issue Date FY: 2022 ( Subtotal = $422,500 )
2022	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	002	3	9/6/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2022	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Biomedical Research and Research Training	001	3	8/26/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$422,500
2022	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Biomedical Research and Research Training	000	2	8/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $422,500

Issue Date FY: 2021 ( Subtotal = $392,292 )
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Biomedical Research and Research Training	000	2	8/23/2021	NON-COMPETING CONTINUATION	$392,292
														Subtotal = $392,292

Issue Date FY: 2020 ( Subtotal = $391,250 )
2020	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Biomedical Research and Research Training	000	1	9/7/2020	NEW	$391,250
														Subtotal = $391,250

Grand Total All Awards = $2,599,800

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Mapping the Dynamic Interactome of Ig-fold Membrane Proteins Using Nanobody-Based Tools

Award Number: R35GM137905

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2031

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