Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Actin filament mechanics and branched network turnover

Award Number: R35GM136656
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/06/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2030

Group Awards By:

View Award Description

Actin filament mechanics and branched network turnover - SUMMARY The assembly of actin filaments into Arp2/3 complex-branched filament networks powers numerous fundamental eukaryotic cellular processes, including motility, endocytosis, and cytokinesis. Reorganization and disassembly of these branched networks recycle actin and regulatory protein components, permitting continual force production and sustained motility. This MIRA proposal integrates biochemical and biophysical experiments and theory to develop predictive models of actin filament and network mechanics, assembly, remodeling, and recycling. Completing the proposed research will fill missing gaps in knowledge of the Arp2/3 complex debranching mechanism, specifically how it is regulated by bound nucleotide and force, how regulatory proteins modulate Arp2/3 complex activity, and the significance of actin isoforms. The proposed research will also determine how the kinetic properties of an RNA helicase motor protein essential for nuclear mRNA export and a purinergic signaling enzyme involved in calcification have adapted to fulfill their physiological roles.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $557,065 )
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	7	4/2/2026	NON-COMPETING CONTINUATION	$557,065
														Subtotal = $557,065

Issue Date FY: 2025 ( Subtotal = $555,820 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	001	6	5/12/2025	COMPETING CONTINUATION	$555,820
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	5	11/6/2024	NON-COMPETING CONTINUATION	$0
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	002	5	6/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $555,820

Issue Date FY: 2024 ( Subtotal = $503,021 )
2024	2024	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	5	1/1/2024	NON-COMPETING CONTINUATION	$452,719
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	001	5	7/23/2024	NON-COMPETING CONTINUATION	$50,302
														Subtotal = $503,021

Issue Date FY: 2023 ( Subtotal = $503,021 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	4	1/20/2023	NON-COMPETING CONTINUATION	$452,719
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	001	4	3/21/2023	NON-COMPETING CONTINUATION	$50,302
														Subtotal = $503,021

Issue Date FY: 2022 ( Subtotal = $532,666 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	001	3	2/8/2022	SUPPLEMENT FOR EXPANSION	$29,645
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	3	2/7/2022	NON-COMPETING CONTINUATION	$452,717
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	002	3	7/14/2022	NON-COMPETING CONTINUATION	$50,304
														Subtotal = $532,666

Issue Date FY: 2021 ( Subtotal = $824,134 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	2	1/29/2021	NON-COMPETING CONTINUATION	$516,751
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	001	2	3/3/2021	NON-COMPETING CONTINUATION	$57,419
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	002	2	9/10/2021	SUPPLEMENT FOR EXPANSION	$249,964
														Subtotal = $824,134

Issue Date FY: 2020 ( Subtotal = $544,524 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	001	1	7/1/2020	SUPPLEMENT FOR EXPANSION	$41,503
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Biomedical Research and Research Training	000	1	4/6/2020	NEW	$503,021
														Subtotal = $544,524

Grand Total All Awards = $4,020,251

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Actin filament mechanics and branched network turnover

Award Number: R35GM136656

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/06/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer