Wednesday, January 15, 2025 1/15/2025

Uncovering new approaches to manipulate and probe biochemical processes with spatial and temporal precision.

Award Number: R35GM136367
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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While advances in imaging technologies are enabling scientists to observe cellular phenomena and protein complexes in increasingly greater detail, our ability to perturb and manipulate cells with equally fine precision have lagged. To better understand the dynamic cellular environment, tools that can selectively perturb biological processes, in real-time, with fast, reversible, tunable, and spatially- selective control are required. A major step forward in this area has come from the field of cellular optogenetics, wherein photosensory proteins are engineered to control various cellular processes with light. Because light can be delivered with fast temporal and subcellular spatial precision, such tools allow unprecedented biological control. In prior work, we developed novel optogenetic tools based on the plant photoreceptor cryptochrome 2 (CRY2), which can be used to precisely manipulate protein interactions, localization, and activity. While these tools have been successful at regulating protein function, improvements and new strategies for optogenetic regulation are needed. In the proposed work, we will usher in a new wave of optogenetic engineering, improving upon existing strategies, extending optogenetic tools into new areas, developing new photoreceptor modules, and testing novel engineering designs to regulate protein function with light. The long term goals of the project are to enable a set of modular precision tools for probing and manipulating biochemical processes with fast temporal control and over spatial scales ranging from subcellular to organismal.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	000	5	11/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $430,372 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	000	5	4/29/2024	NON-COMPETING CONTINUATION	$430,372
														Subtotal = $430,372

Issue Date FY: 2023 ( Subtotal = $430,372 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	000	4	3/22/2023	NON-COMPETING CONTINUATION	$430,372
														Subtotal = $430,372

Issue Date FY: 2022 ( Subtotal = $430,372 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	001	3	6/30/2022	NON-COMPETING CONTINUATION	$43,040
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	000	3	3/1/2022	NON-COMPETING CONTINUATION	$387,332
														Subtotal = $430,372

Issue Date FY: 2021 ( Subtotal = $430,372 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	000	2	6/9/2021	NON-COMPETING CONTINUATION	$430,372
														Subtotal = $430,372

Issue Date FY: 2020 ( Subtotal = $299,957 )
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	000	1	3/24/2020	NEW	$299,957
														Subtotal = $299,957

Grand Total All Awards = $2,021,445

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Uncovering new approaches to manipulate and probe biochemical processes with spatial and temporal precision.

Award Number: R35GM136367

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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