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Machine Learning-Assisted Integrated Optofluidic Nanoplasmonic Biosensing for Precision Immune Profiling and Monitoring

Award Number: R35GM133795
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Machine Learning-Assisted Integrated Optofluidic Nanoplasmonic Biosensing for Precision Immune Profiling and Monitoring Abstract: The intricate and dynamic nature of the immune system demands a comprehensive understanding of its functional behavior for effective prediction and treatment of immune-related diseases. Cytokines, vital for intercellular signaling, offer invaluable insights into a range of diseases, including infections, cancer, autoimmune disorders, and allergy transplantation. Prompt and precise multiparametric cytokine detection at the point of care is essential for comprehending patients' dynamic immune responses. In our previous MIRA project, we developed integrated optofluidic nanoplasmonic biosensing platforms for high-throughput, sensitive, and multiplex cytokine detection from whole blood to single-cell levels. Building on our past accomplishments, we propose to develop high performance integrated optofluidic nanoplasmonic biosensing technologies for immune analysis and incorporate machine learning techniques to enable precision Immune profiling and monitoring for better patient care. The primary objectives of this renewal application are to: 1) advance the next generation of serum immunoassays by integrating the power of machine learning (ML) to engineer state-of-art plasmonic nanomaterials and capture probes with significantly enhanced sensing performance for rapid, reliable and effective diagnosis at point-of-care; 2) Develop ML-enhanced micropillar-based in situ immunoassays for real- time immune monitoring of on-chip in vitro models for high-resolution, high-throughput immune profiling towards personalized immunomodulatory therapies; 3) Establish an innovative integrated method by embedding nanoplasmon rulers within a hydrogel matrix to map the 3D spatiotemporal cytokine secretion profiles of individual immune cells encapsulated in the hydrogel, providing new insights into immune cell behavior and communication in a 3D physiologically relevant context. Our vision is to bridge the gap in our fundamental understanding of the immune system and enhance the diagnostic and predictive power for immune system diseases. The advanced integrated optofluidic nanoplasmonic biosensing platforms, empowered by machine learning, will gear the biologists and clinicians with the ability to rapidly and precisely determine patients' immune statuses. This transformative achievement holds enormous potential for both fundamental research and clinical applications, ultimately leading to improved patient outcomes and more effective therapies for immune-related diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	AUBURN UNIVERSITY	321-A INGRAM HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	6	11/18/2024	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $379,956 )
2024	2024	AUBURN UNIVERSITY	321-A INGRAM HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	6	7/25/2024	COMPETING CONTINUATION	$379,956
														Subtotal = $379,956

Issue Date FY: 2023 ( Subtotal = $375,542 )
2023	2023	AUBURN UNIVERSITY	321-A INGRAM HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	5	8/23/2023	NON-COMPETING CONTINUATION	$375,542
														Subtotal = $375,542

Issue Date FY: 2022 ( Subtotal = $375,542 )
2022	2022	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	4	8/22/2022	NON-COMPETING CONTINUATION	$375,542
														Subtotal = $375,542

Issue Date FY: 2021 ( Subtotal = $625,238 )
2021	2021	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	3	8/2/2021	NON-COMPETING CONTINUATION	$375,542
2021	2021	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	001	3	8/31/2021	SUPPLEMENT FOR EXPANSION	$249,696
														Subtotal = $625,238

Issue Date FY: 2020 ( Subtotal = $375,542 )
2020	2020	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	2	8/10/2020	NON-COMPETING CONTINUATION	$375,542
														Subtotal = $375,542

Issue Date FY: 2019 ( Subtotal = $375,542 )
2019	2019	AUBURN UNIVERSITY	107 SAMFORD HALL	AUBURN	AL	36849	LEE	USA	Biomedical Research and Research Training	000	1	8/16/2019	NEW	$375,542
														Subtotal = $375,542

Grand Total All Awards = $2,507,362

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Machine Learning-Assisted Integrated Optofluidic Nanoplasmonic Biosensing for Precision Immune Profiling and Monitoring

Award Number: R35GM133795

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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