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Evolution of genetic disease risks over time and space

Award Number: R35GM133727
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Evolution of genetic disease risks over time and space - Project summary This research project bridges the gap between evolutionary genetics and genetic epidemiology. In the past few years, a large number of genome-wide association studies have identified thousands of disease susceptibility loci. However, the vast majority of these studies have focused on individuals with European ancestry. Many disease loci have yet to be discovered, and disease-associations that are presently known suffer from ascertainment bias. A major public health challenge is to accurately predict hereditary disease risks in other populations. Previous work has revealed that hereditary disease risks have evolved over human history and that disease risks are correlated with different genetic ancestries. This proposed research plan combines multiple approaches: analysis of ancient and modern genomes, mathematical modeling, and bioinformatics tool development. It examines the evolutionary causes of differences in genetic disease risks across populations, and it will help extend precision medicine to individuals who have diverse ancestries. By applying genomic medicine approaches to ancient DNA, this project will be result in a better understanding of how health and disease have evolved in the recent past. Mathematical models and computer simulations will be used to generate testable predictions about what sorts of genetic architectures contribute the most to health inequities. This project includes development of a novel ancestry painting approach that will improve predictions of hereditary disease risks for individuals whose genomes contain a mix of different ancestries. This project also involves generating improved genetic risk scores that correct for ascertainment bias and evolutionary history while incorporating details of molecular cell biology. The effectiveness of this approach will be assessed using phenotypic data from multiple populations. A major goal of this project is to understand how disease risks have come to vary across the globe, and this work will help extend the benefits of genomic medicine to individuals who have diverse ancestries.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$671 )
2026	2023	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	5	4/2/2026	NON-COMPETING CONTINUATION	-$671
														Subtotal = -$671

Issue Date FY: 2023 ( Subtotal = $376,117 )
2023	2023	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	5	7/11/2023	NON-COMPETING CONTINUATION	$376,117
														Subtotal = $376,117

Issue Date FY: 2022 ( Subtotal = $376,117 )
2022	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	4	7/28/2022	NON-COMPETING CONTINUATION	$376,117
														Subtotal = $376,117

Issue Date FY: 2021 ( Subtotal = $376,117 )
2021	2021	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	3	7/5/2021	NON-COMPETING CONTINUATION	$376,117
														Subtotal = $376,117

Issue Date FY: 2020 ( Subtotal = $376,117 )
2020	2020	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	2	7/21/2020	NON-COMPETING CONTINUATION	$376,117
														Subtotal = $376,117

Issue Date FY: 2019 ( Subtotal = $377,980 )
2019	2019	GEORGIA TECH RESEARCH CORPORATION	505 10TH ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	1	9/3/2019	NEW	$377,980
														Subtotal = $377,980

Grand Total All Awards = $1,881,777

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Evolution of genetic disease risks over time and space

Award Number: R35GM133727

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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