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Integrative Circuit-Host Modeling of Synthetic Gene Networks

Award Number: R35GM133579
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Integrative Circuit-Host Modeling of Synthetic Gene Networks - Abstract Quantitative modeling of gene circuits is fundamentally important to synthetic biology, as it offers the potential to transform circuit engineering from trial-and-error construction to rational design and, hence, facilitates the advance of the ﬁeld. Currently, typical models regard gene circuits as isolated entities and focus only on the biochemical processes within the circuits. Although highly valuable, such a `standard' paradigm has shown to be often incapable of quantitatively, or sometimes even qualitatively, describing circuit behaviors. This limitation arises from multiple factors, among which the overlook of the intimate coupling between circuits and their host is a major cause. My research program aims to discover the fundamental design principles of bacterial gene circuits by harnessing the power of math-based reasoning and tight integration of experiment with theory. In this project, we plan to develop an integrative modeling framework that quantitatively describes gene circuit behaviors in the context of bidirectional circuit-host coupling across multiple scales. To achieve our goal, we will employ a multidisciplinary approach that combines mathematical modeling and experimental molecular biology. We will also build our research on our recent success in the creation of a promising preliminary circuit-host model. For the next few years, our research is organized into three separate but interconnected themes: (1) Develop a generalized framework of circuit-host resource allocation, (2) Build a capacity to account for circuits in varying environments, and (3) Establish a understanding of gene circuit behaviors in ecological contexts. These themes of research will involve the development of generalized theoretical foundations (Theme 1) as well as the investigation of speciﬁc key challenges relating to future real-world applications (Theme 2 and 3). The proposed work promises to yield an integrative mathematical framework that quantitatively describes and predicts circuit behaviors with the incorporation of host physiology and circuit-host coupling across multiple scales. Such a framework will help to shift the paradigms of gene circuit engineering from trial-and-error creation to rational design and forward engineering. Additionally, it will advance our understanding of the regulatory dynamics underlying bacterial gene networks and also offer quantitative insights into complex bacterial physiology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	5	1/16/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $382,218 )
2023	2023	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	5	9/25/2023	NON-COMPETING CONTINUATION	$382,218
														Subtotal = $382,218

Issue Date FY: 2022 ( Subtotal = $382,218 )
2022	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	4	9/23/2022	NON-COMPETING CONTINUATION	$382,218
														Subtotal = $382,218

Issue Date FY: 2021 ( Subtotal = $382,218 )
2021	2021	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	3	5/5/2021	NON-COMPETING CONTINUATION	$382,218
														Subtotal = $382,218

Issue Date FY: 2020 ( Subtotal = $373,428 )
2020	2020	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	2	6/2/2020	NON-COMPETING CONTINUATION	$373,428
														Subtotal = $373,428

Issue Date FY: 2019 ( Subtotal = $364,638 )
2019	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	1	7/31/2019	NEW	$364,638
														Subtotal = $364,638

Grand Total All Awards = $1,884,720

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Integrative Circuit-Host Modeling of Synthetic Gene Networks

Award Number: R35GM133579

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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