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Leveraging environmental drivers to predict vector-borne disease transmission

Award Number: R35GM133439
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Leveraging environmental drivers to predict vector-borne disease transmission - Project Summary The overarching goal of my research program is to understand the dynamics of ecological systems and their influence on diseases in humans, plants, and animals to improve the health and wellbeing of humans and ecosystems. Vector-borne diseases are a growing public health problem that are intimately linked to climate, land use, and other environmental changes. Our current and future research is focused on understanding changes in vector-borne disease burdens in response to global change. Predictive approaches that mechanistically link environmental change to disease dynamics are necessary to disrupt transmission and to sustainably control outbreaks. Research in my lab uses a diverse quantitative toolkit and emerging sources of data to predict disease dynamics, uncover environmental mechanisms for transmission, attribute impacts of global change, and forecast changes in the landscape of infectious disease. In the next five years, we will build on our understanding of climatic drivers of vector-borne diseases to study the impacts of climate extremes, the limitations on and drivers of vector species range expansions, and the role of adaptive (co)evolution. We will disentangle the multidimensional effects of land use change on vector-borne diseases by combining hypothesis testing, novel causal inference methods, and geospatial datasets to uncover the land use niches for disease transmission. Our focal systems include dengue, malaria, leishmaniasis, schistosomiasis, yellow fever, Lyme disease, and their mosquito, sandfly, and tick vectors. Our work combines publicly available environmental and epidemiological data and partner-engaged research with vector control and health agencies. We apply mechanistic mathematical models, machine learning, econometric causal inference, empirical dynamic modeling methods, and other quantitative tools. We also conduct primary empirical research on mosquito and parasite thermal adaptation on the Western treehole mosquito and its ciliate parasite. We are now witnessing unprecedented impacts of anthropogenic climate and land use change alongside expansions and resurgences of vector-borne and zoonotic diseases. At the same time, expanding technological and computational capacity are accelerating the pace of infectious disease dynamics research. This is an exciting and critical time to study linkages between human and planetary health, and my research program is at the forefront of this emerging field. By discovering mechanistic linkages between environmental change and disease transmission, we can design more proactive control measures, develop policy that benefits people and the environment, and prevent and reverse the worst impacts of anthropogenic change on health and their disproportionate impacts on marginalized populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $423,500 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	6	4/28/2025	COMPETING CONTINUATION	$423,500
														Subtotal = $423,500

Issue Date FY: 2023 ( Subtotal = $391,250 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	5	8/17/2023	NON-COMPETING CONTINUATION	$391,250
														Subtotal = $391,250

Issue Date FY: 2022 ( Subtotal = $468,900 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	4	9/12/2022	NON-COMPETING CONTINUATION	$391,250
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	4	9/15/2022	SUPPLEMENT FOR EXPANSION	$77,650
														Subtotal = $468,900

Issue Date FY: 2021 ( Subtotal = $391,250 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	3	9/13/2021	NON-COMPETING CONTINUATION	$391,250
														Subtotal = $391,250

Issue Date FY: 2020 ( Subtotal = $706,650 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	2	9/21/2020	NON-COMPETING CONTINUATION	$654,082
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	1	6/30/2020	SUPPLEMENT FOR EXPANSION	$52,568
														Subtotal = $706,650

Issue Date FY: 2019 ( Subtotal = $391,250 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	1	8/14/2019	NEW	$391,250
														Subtotal = $391,250

Grand Total All Awards = $2,772,800

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Leveraging environmental drivers to predict vector-borne disease transmission

Award Number: R35GM133439

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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