Sunday, October 1, 2023
10/1/2023
ABSTRACT This supplement to R35 GM131816 is directed towards the purchase of a Shimadzu Nexera™ Ultra High Performance Liquid Chromatograph (UHPLC) for the efficient determination of enantiomeric excess of organic compounds. Because of the differing biological activities of enantiomers, efficient methods are required to prepare bioactive molecules in high enantiomeric purity. Recognizing this important need, the development of new methods to prepare highly enantioenriched organic compounds is a major focus of the parent research program. The proposed UHPLC instrument will replace a rapidly deteriorating 14-year-old HPLC, which has been a critical workhorse instrument to enable the R35-supported research.
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