Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Epithelial biology: morphogenesis and damage signaling

Award Number: R35GM130388
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2029

Group Awards By:

View Award Description

Epithelial biology: morphogenesis and damage signaling - PROJECT SUMMARY Epithelia are the core cell type of animals, and constitute the most widespread and ancient mode of tissue architecture. My lab uses a distinctive set of multidisciplinary strategies to study fundamental questions of epithelial biology using Drosophila, leveraging deep evolutionary conservation to uncover general principles applicable across phylogeny. The research proposed in this MIRA renewal tackles basic mechanisms underlying epithelial organ shaping and the total body’s response to epithelial injury. Both goals -- one in which we have a long track record and another stimulated by discoveries during the previous funding period-- build on my laboratory’s 20-year NIGMS-funded research program. In one direction we will investigate how developing epithelia respond not just to intracellular forces, but also to resistance from the extracellular matrix. This understudied question is central to the morphogenetic movements that allow organs to attain the specific forms required for function. Our previous work has shown how an organ can be sculpted by finely patterned mechanical properties of the basement membrane that underlies all epithelia. We will determine the mechanisms that regulate conserved matrix components and modifiers to achieve precise mechanical patterning, and then exploit this knowledge to manipulate tissue shape in a predictable fashion. In the other direction, we will explore the whole-body response to epithelial barrier damage. While the local wound response is well-characterized and conserved across many phyla, animals also have systemic wound responses mediated by signaling factors that communicate with distant organs. The mechanisms and impact of these humoral responses, which include but are not limited to inflammation, are poorly understood compared to the antimicrobial immune response triggered in parallel; they may include unappreciated signaling molecules and exotic forms of signal transmission alongside well-known pathways such as TNF. Leveraging the strengths of Drosophila for discovery biology, we will induce sterile injury in adult epithelial tissues and identify signaling axes that communicate between the organ of insult and responding tissues to promote homeostasis and health. This goal will include a comprehensive analysis of TNF signaling in the adult, and investigation of differences between normal tissue repair and that triggered by chronic inflammation. The proposed experiments tackle these key questions by combining the traditional strengths of Drosophila genetics with advanced imaging and new biochemical techniques, empowered by collaborations. Our results will enhance understanding of conserved mechanisms that generate functional epithelial organs during development, and lay the foundation for addressing disorders driven by epithelial damage and pathology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $829,155 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	119 CALIFORNIA HALL	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	000	8	2/12/2026	NON-COMPETING CONTINUATION	$829,155
														Subtotal = $829,155

Issue Date FY: 2025 ( Subtotal = $826,172 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	003	7	8/8/2025	NON-COMPETING CONTINUATION	$82,617
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	004	7	8/15/2025	NON-COMPETING CONTINUATION	$0
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	7	2/21/2025	NON-COMPETING CONTINUATION	$743,555
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	6	11/25/2024	COMPETING CONTINUATION	$0
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	5	2/12/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $826,172

Issue Date FY: 2024 ( Subtotal = $853,020 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	6	2/22/2024	COMPETING CONTINUATION	$853,020
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	5	2/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $853,020

Issue Date FY: 2023 ( Subtotal = $819,706 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	5	3/24/2023	NON-COMPETING CONTINUATION	$81,969
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	5	12/8/2022	NON-COMPETING CONTINUATION	$737,737
														Subtotal = $819,706

Issue Date FY: 2022 ( Subtotal = $819,706 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	4	1/7/2022	NON-COMPETING CONTINUATION	$737,737
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	4	7/25/2022	NON-COMPETING CONTINUATION	$81,969
														Subtotal = $819,706

Issue Date FY: 2021 ( Subtotal = $819,706 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	3	12/7/2020	NON-COMPETING CONTINUATION	$737,737
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	3	3/4/2021	NON-COMPETING CONTINUATION	$81,969
														Subtotal = $819,706

Issue Date FY: 2020 ( Subtotal = $819,706 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	2	1/14/2020	NON-COMPETING CONTINUATION	$819,706
														Subtotal = $819,706

Issue Date FY: 2019 ( Subtotal = $697,649 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	1	12/31/2018	NEW	$697,649
														Subtotal = $697,649

Grand Total All Awards = $6,484,820

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Epithelial biology: morphogenesis and damage signaling

Award Number: R35GM130388

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer