Sunday, November 24, 2024 11/24/2024

Discovery and Development of Organic Reactions Catalyzed by Transition Metals Valuable for Medicinal Chemistry

Award Number: R35GM130387
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary We are requesting administrative equipment supplemental funds to acquire a preparative HPLC that allows for automated purifications of materials that are difficult to separate by flash column chromatography. This instrument will significantly increase productivity and workflow towards the parent goals of R35GM130387 by enabling rapid purification of crude reactions containing non-volatile products from catalytic reactions on complex molecules. Currently, our research group does not have access to preparative HPLC, let alone preparative systems with the software that allows automated transfer of conditions from analytical to preparative HPLC. A major current focus of researchers studying catalytic reactions, including those of the PI’s laboratory, is to create systems that introduce new functional groups in complex molecules with high selectivity. Multiple projects supported by the PI’s current NIH funding address this general goal and would benefit from this new capability in our group. These include the regioselective borylation, silylation, and alkylation of (sp3)C-H bonds in natural products and complex molecules from medicinal chemistry, the selective oxidation and subsequent derivatization of complex terpenes, and reactions catalyzed by artificial metalloenzymes, including reactions in whole cells. With a method to rapidly purify the products of these reactions, the isomers of the product formed can be identified, and progress on these research goals will be greatly accelerated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	7	11/11/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,030,601 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	006	7	8/21/2024	SUPPLEMENT FOR EXPANSION	$143,163
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	005	7	6/10/2024	SUPPLEMENT FOR EXPANSION	$55,820
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	004	7	5/20/2024	NON-COMPETING CONTINUATION	$83,162
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	003	7	1/22/2024	NON-COMPETING CONTINUATION	$748,456
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	5	1/17/2024	SUPPLEMENT FOR EXPANSION	-$116
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	6	1/17/2024	COMPETING CONTINUATION	$1,215
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	5	1/17/2024	NON-COMPETING CONTINUATION	-$1,099
														Subtotal = $1,030,601

Issue Date FY: 2023 ( Subtotal = $1,012,862 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	007	6	5/31/2023	COMPETING CONTINUATION	$74,568
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	005	5	5/12/2023	SUPPLEMENT FOR EXPANSION	-$48,469
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	5	12/2/2022	NON-COMPETING CONTINUATION	$709,158
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	006	6	5/15/2023	SUPPLEMENT FOR EXPANSION	$48,469
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	5	1/6/2023	SUPPLEMENT FOR EXPANSION	$83,089
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	004	6	5/12/2023	COMPETING CONTINUATION	$526,891
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	003	5	5/12/2023	NON-COMPETING CONTINUATION	-$459,639
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	5	4/4/2023	NON-COMPETING CONTINUATION	$78,795
														Subtotal = $1,012,862

Issue Date FY: 2022 ( Subtotal = $871,042 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	4	12/22/2021	NON-COMPETING CONTINUATION	$709,158
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	4	6/28/2022	NON-COMPETING CONTINUATION	$78,795
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	4	12/23/2021	SUPPLEMENT FOR EXPANSION	$83,089
														Subtotal = $871,042

Issue Date FY: 2021 ( Subtotal = $862,063 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	3	12/9/2020	NON-COMPETING CONTINUATION	$709,158
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	003	3	7/16/2021	SUPPLEMENT FOR EXPANSION	$20,958
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	3	2/12/2021	NON-COMPETING CONTINUATION	$78,795
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	3	12/14/2020	SUPPLEMENT FOR EXPANSION	$53,152
														Subtotal = $862,063

Issue Date FY: 2020 ( Subtotal = $787,953 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	2	1/3/2020	NON-COMPETING CONTINUATION	$709,158
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	2	3/5/2020	NON-COMPETING CONTINUATION	$78,795
														Subtotal = $787,953

Issue Date FY: 2019 ( Subtotal = $841,524 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Biomedical Research and Research Training	000	1	12/31/2018	NEW	$687,888
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	1	6/10/2019	SUPPLEMENT FOR EXPANSION	$153,636
														Subtotal = $841,524

Grand Total All Awards = $5,406,045

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Discovery and Development of Organic Reactions Catalyzed by Transition Metals Valuable for Medicinal Chemistry

Award Number: R35GM130387

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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