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Regulation of mRNA Fate

Award Number: R35GM130361
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Regulation of mRNA Fate - Project Summary This renewal application focuses on studying the roles of messenger RNA binding proteins (mRBPs) in the regulation of alternative splicing and mRNA translation. Our approach uses a combination of genomics, molecular biology and biochemistry to gain fundamental insights to mRBP function and targets in human cells. During the previous funding period we discovered functional RNA elements that control pre-mRNA splicing and mRNA translation. The goal of the next funding period is to determine how these sequences regulate gene expression. Another goal of this project is to determine how the process of alternative splicing impacts protein synthesis. It is well established that alternative splicing expands the coding potential of protein coding genes, but we and others have also discovered that mRNA isoforms can exhibit different patterns of translational control and mRNA stability. We will elucidate the mechanisms through which alternative splicing influences translation by discovering isoform-specific cis-acting RNA elements that influence polyribosome association. To accomplish this goal, we will use composite cell lines that contain a full complement of human and chimpanzee chromosomes. These novel models will enable the discovery of single nucleotide changes that cause allele- specific gene expression within the identical trans-regulatory environment. We can then determine the mechanisms of action for these regulatory elements using biochemical and molecular approaches, such as RNA affinity chromatography and mRNA reporter assays. Together, this project will significantly advance the understanding ofr how mRBPs function in post-transcriptional control of gene expression in human cells and provide key information for novel strategies to treat inherited diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $823,058 )
2025	2025	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	003	7	8/6/2025	NON-COMPETING CONTINUATION	$411,529
2025	2025	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	002	6	4/16/2025	COMPETING CONTINUATION	$411,529
2025	2024	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	002	6	4/16/2025	COMPETING CONTINUATION	$692
2025	2024	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	000	6	11/5/2024	COMPETING CONTINUATION	$0
2025	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	001	5	4/16/2025	NON-COMPETING CONTINUATION	-$692
														Subtotal = $823,058

Issue Date FY: 2024 ( Subtotal = $410,485 )
2024	2024	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	001	6	7/12/2024	COMPETING CONTINUATION	$410,485
2024	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	000	5	7/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $410,485

Issue Date FY: 2023 ( Subtotal = $371,425 )
2023	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	000	5	12/14/2022	NON-COMPETING CONTINUATION	$334,283
2023	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	001	5	3/24/2023	NON-COMPETING CONTINUATION	$37,142
														Subtotal = $371,425

Issue Date FY: 2022 ( Subtotal = $371,425 )
2022	2022	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	001	4	7/20/2022	NON-COMPETING CONTINUATION	$37,143
2022	2022	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	000	4	2/11/2022	NON-COMPETING CONTINUATION	$334,282
														Subtotal = $371,425

Issue Date FY: 2021 ( Subtotal = $371,425 )
2021	2021	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	000	3	12/11/2020	NON-COMPETING CONTINUATION	$334,282
2021	2021	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	001	3	3/4/2021	NON-COMPETING CONTINUATION	$37,143
														Subtotal = $371,425

Issue Date FY: 2020 ( Subtotal = $371,425 )
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	000	2	12/27/2019	NON-COMPETING CONTINUATION	$334,282
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	001	2	3/12/2020	NON-COMPETING CONTINUATION	$37,143
														Subtotal = $371,425

Issue Date FY: 2019 ( Subtotal = $371,425 )
2019	2019	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Biomedical Research and Research Training	000	1	12/26/2018	NEW	$371,425
														Subtotal = $371,425

Grand Total All Awards = $3,090,668

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Regulation of mRNA Fate

Award Number: R35GM130361

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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