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Mass Spectrometry Measurements for Complex PTMs

Award Number: R35GM130354
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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Mass Spectrometry Measurements for Complex PTMs - Abstract: Recombinant protein expression technology has revolutionized human health research, enabling scientists to generate large quantities of protein for small-molecule drug discovery campaigns, for the development of protein-based drugs, and for studying protein structure and function. Yet while researchers are adept at producing proteins with known genetic sequences, they possess entirely inadequate knowledge about the protein's post-translational modifications, both during recombinant expression and when the proteins are isolated from endogenous sources. Alterations in a protein's post-translational modifications can change the protein from an active enzyme to a dead one; they can change a protein-based drug from a life-saving molecule to one that is either ineffective or worse, dangerously immunogenic; these seemingly simple “add- ons” to proteins can be the defining features that determine whether the protein functions as designed or not. Characterizing proteins' PTMs is a necessary prerequisite for identifying disease states, modulating protein binding and function, and producing safe and effective protein-based drugs and vaccines. The long term goals of my research program are to expedite the analysis of post-translational modifications (PTMs) on proteins, to use these analytical tools to answer critical health-related challenges, and to widely distribute the technology. We are pursuing both near-term advancements, such as developing a robust solution to quantifying aberrant disulfide bonds in recombinant proteins, as well as long-range, revolutionary changes in the way proteins are analyzed, by laying the foundational infrastructure needed to bring artificial intelligence solutions to the field of PTM analysis. We will develop and launch these technologies in the context of meaningful biological problems where field advancements cannot be made without information about proteins' PTMs. Solutions in the fields of HIV vaccine design, cancer treatment, and antibody therapy will be targeted first.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$73,581 )
2025	2023	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	000	5	11/6/2024	NON-COMPETING CONTINUATION	$0
2025	2023	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	001	5	5/28/2025	NON-COMPETING CONTINUATION	-$73,581
														Subtotal = -$73,581

Issue Date FY: 2023 ( Subtotal = $377,124 )
2023	2023	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	000	5	2/7/2023	NON-COMPETING CONTINUATION	$377,124
														Subtotal = $377,124

Issue Date FY: 2022 ( Subtotal = $377,124 )
2022	2022	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	000	4	1/5/2022	NON-COMPETING CONTINUATION	$339,410
2022	2022	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	001	4	6/28/2022	NON-COMPETING CONTINUATION	$37,714
														Subtotal = $377,124

Issue Date FY: 2021 ( Subtotal = $377,124 )
2021	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	000	3	1/22/2021	NON-COMPETING CONTINUATION	$339,410
2021	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	001	3	2/26/2021	NON-COMPETING CONTINUATION	$37,714
														Subtotal = $377,124

Issue Date FY: 2020 ( Subtotal = $377,124 )
2020	2020	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	000	2	1/9/2020	NON-COMPETING CONTINUATION	$377,124
														Subtotal = $377,124

Issue Date FY: 2019 ( Subtotal = $377,124 )
2019	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Biomedical Research and Research Training	000	1	1/18/2019	NEW	$377,124
														Subtotal = $377,124

Grand Total All Awards = $1,812,039

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Mass Spectrometry Measurements for Complex PTMs

Award Number: R35GM130354

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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