Tuesday, November 4, 2025 11/4/2025

Biomolecular Recognition with Synthetic Protein Mimics

Award Number: R35GM130333
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Biomolecular Recognition with Synthetic Protein Mimics - Abstract Interactions of proteins with other biomolecules regulate fundamental cellular events and misregulation of these interactions leads to disease states. Proteins often utilize small folded domains for recognition of other biomolecules. The basic hypothesis guiding our research is that by mimicking these folded domains we can specifically inhibit chosen protein complex formation with rationally designed synthetic molecules. Based on this hypothesis, we have developed a suite of Protein Domain Mimics (PDMs) that faithfully reproduce binding epitopes on protein surfaces. This work has created a foundation for the development of a new class of structure–based therapeutics. Equipped with our platform of PDMs, we will focus on a currently intractable class of targets in IDPs or Intrinsically Disordered Proteins. Therapeutic targeting of intrinsically disordered proteins is attractive because they interact with a multitude of partners and influence numerous signaling pathways. However, targeting of IDPs remains underexplored. We hypothesize that we can engage cellular IDPs with biomolecular receptors and scavenge them away from their natural binding partners. This strategy would constitute a distinct mechanism for targeting of IDP-mediated protein-protein interactions. In a new direction for the group, we will develop encodable ligands to sequence-specifically target double-stranded RNA, the most abundant class of cellular RNA. dsRNA has proven to be recalcitrant to therapeutic intervention; although, it is central to many biological events. In preliminary results, we have discovered a new class of molecular scaffold that can be engineered to provide sequence-specific recognition of dsRNA. Studies in each Aim will advance general approaches to inhibit protein-protein and protein-RNA complexes, and establish PDMs as distinct constructs spanning the molecular size space between small molecules and proteins.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $737,432 )
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	002	7	1/16/2025	NON-COMPETING CONTINUATION	$663,688
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	003	7	8/6/2025	NON-COMPETING CONTINUATION	$73,744
2025	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	6	11/22/2024	COMPETING CONTINUATION	$0
2025	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	5	12/31/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $737,432

Issue Date FY: 2024 ( Subtotal = $779,055 )
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	005	6	9/4/2024	SUPPLEMENT FOR EXPANSION	$41,623
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	004	6	3/7/2024	COMPETING CONTINUATION	$737,432
2024	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	003	5	3/1/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	002	5	3/1/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	5	3/1/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	5	3/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $779,055

Issue Date FY: 2023 ( Subtotal = $827,963 )
2023	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	003	5	5/10/2023	SUPPLEMENT FOR EXPANSION	$12,577
2023	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	5	1/19/2023	NON-COMPETING CONTINUATION	$627,212
2023	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	004	5	7/31/2023	SUPPLEMENT FOR EXPANSION	$76,753
2023	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	002	5	4/4/2023	NON-COMPETING CONTINUATION	$69,690
2023	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	5	1/20/2023	SUPPLEMENT FOR EXPANSION	$41,731
														Subtotal = $827,963

Issue Date FY: 2022 ( Subtotal = $970,360 )
2022	2022	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	002	4	5/26/2022	SUPPLEMENT FOR EXPANSION	$190,000
2022	2022	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	4	1/14/2022	NON-COMPETING CONTINUATION	$627,211
2022	2022	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	4	1/19/2022	SUPPLEMENT FOR EXPANSION	$83,458
2022	2022	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	003	4	6/28/2022	NON-COMPETING CONTINUATION	$69,691
														Subtotal = $970,360

Issue Date FY: 2021 ( Subtotal = $828,633 )
2021	2021	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	3	2/12/2021	NON-COMPETING CONTINUATION	$696,902
2021	2021	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	002	3	8/5/2021	SUPPLEMENT FOR EXPANSION	$41,731
2021	2021	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	3	7/9/2021	SUPPLEMENT FOR EXPANSION	$90,000
														Subtotal = $828,633

Issue Date FY: 2020 ( Subtotal = $715,088 )
2020	2020	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	2	1/15/2020	NON-COMPETING CONTINUATION	$640,088
2020	2020	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	001	2	5/25/2020	SUPPLEMENT FOR EXPANSION	$75,000
														Subtotal = $715,088

Issue Date FY: 2019 ( Subtotal = $412,838 )
2019	2019	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Biomedical Research and Research Training	000	1	1/29/2019	NEW	$412,838
														Subtotal = $412,838

Grand Total All Awards = $5,271,369

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Biomolecular Recognition with Synthetic Protein Mimics

Award Number: R35GM130333

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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