Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Origins of Cell Geometry

Award Number: R35GM130327
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2029

Group Awards By:

View Award Description

Origins of Cell Geometry - Abstract Cells are highly complex living nanomachines with beautiful structures of great precision. This is true not only for free living organisms like ciliates or radiolarians, but also for cells inside the human body. These complicated structures are directly linked to the physiological functions of cells, and alterations in cell geometry are a hallmark of many disease states. Yet in most cases we have almost no information about how cells determine their geometry at the level of organelle size and shape. Thus, understanding the origins of cell geometry remains a fundamental unsolved problem in cell biology. Part of the challenge is that cell geometry involves multiple spatial scales ranging from molecules up to the whole cell. Spanning this gap between scales requires us to go beyond traditional molecular biology approaches and bring in methods from physics and engineering. For this reason my proposal is based on an integrated combination of approaches, using several different model organisms and cell types to address the origins of cell geometry at several different size scales. At the level of single organelles, I will continue to probe the mechanism of flagellar length control as a paradigm for organelle size regulation, with a focus on learning how cells can sense the length of their flagella. At a larger scale, we will continue our development of the classic model organism, Stentor coeruleus, as a genomic model system for analyzing global cell morphogenesis and regeneration. Using Stentor, we intend to pursue the two linked questions of how a cell knows that is geometry has been perturbed, and what molecules it uses to encode positional information needed to direct the re-assembly of a correct cell geometry. Both of these questions that have general significance to all cell types but are particularly easy to study in Stentor. Our proposed work is unified by the focus on a single question – where does geometry come from inside a cell. We will use different model systems to address different aspects of this question, but in all cases we will take an interdisciplinary approach that combines tools of genetics, genomics, microscopy, image analysis, and mathematical modeling.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $678,955 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	8	1/15/2026	NON-COMPETING CONTINUATION	$611,060
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	8	3/10/2026	NON-COMPETING CONTINUATION	$67,895
														Subtotal = $678,955

Issue Date FY: 2025 ( Subtotal = $783,918 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	006	7	8/20/2025	SUPPLEMENT FOR EXPANSION	$87,469
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	003	7	1/23/2025	NON-COMPETING CONTINUATION	$611,060
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	004	7	8/14/2025	NON-COMPETING CONTINUATION	$67,895
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	005	7	8/15/2025	NON-COMPETING CONTINUATION	$0
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	6	12/10/2024	SUPPLEMENT FOR EXPANSION	$17,494
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	6	11/22/2024	COMPETING CONTINUATION	$0
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Biomedical Research and Research Training	002	5	1/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $783,918

Issue Date FY: 2024 ( Subtotal = $678,955 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	6	1/19/2024	COMPETING CONTINUATION	$678,955
														Subtotal = $678,955

Issue Date FY: 2023 ( Subtotal = $649,914 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	5	4/4/2023	NON-COMPETING CONTINUATION	$64,992
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	5	1/6/2023	NON-COMPETING CONTINUATION	$584,922
														Subtotal = $649,914

Issue Date FY: 2022 ( Subtotal = $649,914 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	4	2/4/2022	NON-COMPETING CONTINUATION	$584,922
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	4	7/20/2022	NON-COMPETING CONTINUATION	$64,992
														Subtotal = $649,914

Issue Date FY: 2021 ( Subtotal = $649,914 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	3	2/1/2021	NON-COMPETING CONTINUATION	$584,922
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	3	4/22/2021	NON-COMPETING CONTINUATION	$64,992
														Subtotal = $649,914

Issue Date FY: 2020 ( Subtotal = $648,271 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	2	1/28/2020	NON-COMPETING CONTINUATION	$583,443
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	001	2	3/12/2020	NON-COMPETING CONTINUATION	$64,828
														Subtotal = $648,271

Issue Date FY: 2019 ( Subtotal = $570,513 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Biomedical Research and Research Training	000	1	2/1/2019	NEW	$570,513
														Subtotal = $570,513

Grand Total All Awards = $5,310,354

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Origins of Cell Geometry

Award Number: R35GM130327

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer