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Characterizing modes of natural selection via diverse ancient and modern samples

Award Number: R35GM128946
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Characterizing modes of natural selection via diverse ancient and modern samples - Project Summary In the last thirteen years, analysis of ancient genomes suggests that population admixtures are a dominant feature of human history. Admixture between populations leads to genetic exchange between populations, and this provides an opportunity to introduce new genetic variation much more rapidly than waiting for mutations to occur naturally. Analysis of Neanderthal, Denisovan and ancient modern human genomes suggests that admixture has occurred at different time scales in the past. We are only beginning to understand how genetic variation that is introduced during an admixture event has been evolving in the recipient populations. Evolutionary forces like demographic history and natural selection will also affect the frequency distributions of these mutations in recipient populations. The goal of this research project is to develop statistical methods and computational approaches that can be applied to admixed genomes to investigate how admixture shapes patterns of genetic variation and how it facilitates adaptations. As admixed genomes are mosaics of different ancestries, we can study genetic variation in these genomes to gain insights into the histories of both recipient and donor populations. For example, we can identify genetic variation that help recipient populations adapt to new environments. We will also leverage genetic patterns of admixed genomes to characterize how natural selection acted on genetic variation after very recent admixture events. Finally, with our methods, we can also gain insight into the structure present in the donor populations even if only a handful of genomes exists for these populations. In summary, the methods and the empirical approaches proposed here will be useful to elucidate how different contributions from a complex web of population interactions has affected the evolution of our species.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $373,063 )
2026	2026	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	8	6/19/2026	NON-COMPETING CONTINUATION	$373,063
														Subtotal = $373,063

Issue Date FY: 2025 ( Subtotal = $373,063 )
2025	2025	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	7	7/10/2025	NON-COMPETING CONTINUATION	$373,063
2025	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	6	11/5/2024	COMPETING CONTINUATION	$0
2025	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	5	2/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $373,063

Issue Date FY: 2024 ( Subtotal = $410,362 )
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	6	5/31/2024	COMPETING CONTINUATION	$410,362
2024	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	5	5/31/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $410,362

Issue Date FY: 2022 ( Subtotal = $380,192 )
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	5	9/19/2022	NON-COMPETING CONTINUATION	$380,192
														Subtotal = $380,192

Issue Date FY: 2021 ( Subtotal = $379,863 )
2021	2021	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	4	8/6/2021	NON-COMPETING CONTINUATION	$379,863
														Subtotal = $379,863

Issue Date FY: 2020 ( Subtotal = $379,456 )
2020	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	3	8/18/2020	NON-COMPETING CONTINUATION	$379,456
														Subtotal = $379,456

Issue Date FY: 2019 ( Subtotal = $379,129 )
2019	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	2	8/5/2019	NON-COMPETING CONTINUATION	$379,129
														Subtotal = $379,129

Issue Date FY: 2018 ( Subtotal = $378,726 )
2018	2018	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	1	9/19/2018	NEW	$378,726
														Subtotal = $378,726

Grand Total All Awards = $3,053,854

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Characterizing modes of natural selection via diverse ancient and modern samples

Award Number: R35GM128946

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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