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CATALYTIC PLATFORMS USING AROMATIC IONS AND OTHER CHARGED SPECIES

Award Number: R35GM127135
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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CATALYTIC PLATFORMS USING AROMATIC IONS AND OTHER CHARGED SPECIES - Project Summary. Catalysis has long been a potent force for advancing biomedical research by enabling the construction of biologically important molecules with ever-increasing speed, efficiency, and versatility. One of the most potent driving forces for progress in the area of catalysis has been the discovery of new catalytic platforms and concepts. The proposed research program is broadly focused on advancing the area of catalysis through the development of novel catalytic platforms, concepts, and methods. In particular, we have developed two generic catalytic strategies with broad applicability over a wide array of reaction types. In the first program, we have helped to pioneer the area of electrophotocatalysis, which combines the power of light and electrical energy within a single catalyst to promote challenging chemical reactions. Especially, we have introduced trisaminocyclopropenium (TAC) ions as a novel class of electrophotocatalyst; these catalysts have proven to be useful for a number of transformations, including C–H bond functionalizations and olefin derivatizations. The current application seeks to leverage electrophotocatalysis to realize other challenging, unprecedented reactions, especially those requiring very high redox potentials or involving multiple redox events. In the second program, we have pioneered the area of catalytic carbonyl-olefin metathesis, using hydrazine catalysis. This foundational capability enables a wide range of potentially advantageous synthetic methods. The current application seeks to make major advances to this program by designing highly reactive, next-generation catalysts that greatly expand the scope of substrates that can be engaged. We also aim to apply this mode of catalysis to useful new chemical methods, and to develop related catalytic platforms using these general principles. These and other investigations into the use of novel ideas in catalysis will continue to serve as a stimulus for advancements in chemical synthesis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $511,049 )
2025	2025	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	002	8	7/21/2025	NON-COMPETING CONTINUATION	$511,049
2025	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	7	11/6/2024	NON-COMPETING CONTINUATION	$0
2025	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	001	5	12/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $511,049

Issue Date FY: 2024 ( Subtotal = $511,422 )
2024	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	7	6/14/2024	NON-COMPETING CONTINUATION	$511,422
														Subtotal = $511,422

Issue Date FY: 2023 ( Subtotal = $511,764 )
2023	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	6	6/23/2023	COMPETING CONTINUATION	$511,764
														Subtotal = $511,764

Issue Date FY: 2022 ( Subtotal = $472,427 )
2022	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	5	6/9/2022	NON-COMPETING CONTINUATION	$472,427
														Subtotal = $472,427

Issue Date FY: 2021 ( Subtotal = $472,243 )
2021	2021	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	4	7/15/2021	NON-COMPETING CONTINUATION	$472,243
														Subtotal = $472,243

Issue Date FY: 2020 ( Subtotal = $472,045 )
2020	2020	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	3	6/18/2020	NON-COMPETING CONTINUATION	$472,045
														Subtotal = $472,045

Issue Date FY: 2019 ( Subtotal = $471,835 )
2019	2019	CORNELL UNIVERSITY, INC	373 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	2	6/10/2019	NON-COMPETING CONTINUATION	$471,835
														Subtotal = $471,835

Issue Date FY: 2018 ( Subtotal = $447,421 )
2018	2018	CORNELL UNIVERSITY, INC	373 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	1	7/1/2018	NEW	$447,421
														Subtotal = $447,421

Grand Total All Awards = $3,870,206

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CATALYTIC PLATFORMS USING AROMATIC IONS AND OTHER CHARGED SPECIES

Award Number: R35GM127135

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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