Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

The Role of Cryptochromes in environmental regulation of growth

Award Number: R35GM125003
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/04/2017
PERIOD OF PERFORMANCE END DATE: 05/31/2029

Group Awards By:

View Award Description

The Role of Cryptochromes in environmental regulation of growth - ABSTRACT A fundamental question in biology that has yet to be answered is how an organism's environment regulates its growth and development. Unlike animals, plants neither have specific organs that see or hear various environmental stimuli nor can they move around to avoid adverse conditions. Although lacking a brain, plants can successfully integrate internal and external cues and make appropriate decisions about growth. In contrast to animals, growth in plants occurs post-embryonically, to produce new organs and for the growth and modification of existing forms to adapt to the local environment. Light is among the most relevant environmental signals because it not only drives photosynthesis but also provides critical information about the local growth environment as well as diurnal and seasonal timing. Over the next few years, my laboratory will aim to understand the molecular mechanisms by which a plant perceives and responds to its light environment. To address our questions, we will use cryptochromes (CRYs), the UV-A/blue light photoreceptors, as they form the interface between the light environment and the organism. CRYs are present in diverse organisms, including humans, where they regulate circadian rhythms and several physiological processes, like metabolism, growth, and magnetoreception. We will obtain mechanistic insights on how CRY regulates gene expression at the cellular level, which leads to morphological changes at the organismal level. We will also determine how light and the newly identified CRY2-associated molecules that we have discovered function in CRY-mediated signaling pathways. Also, our research will unravel the novel mechanisms by which CRYs, through their interaction with the RNA-binding proteins that we have discovered, control RNA metabolism, specifically that of methylated RNAs (m6A). m6A is an RNA modification that controls its fate as a reversible regulatory mark, and disruption of RNA methylation leads to growth defects in plants and is linked to several human diseases. We will also address how CRYs integrate environmental signals and modify chromatin through their interaction with chromatin remodelers, whose findings will fill a large void in this field. The success of this study will significantly improve crop productivity to feed the growing human population and aid in the development of optogenetic tools to target neuronal disorders. In humans, disruption of CRY activity is associated with many human disorders, including cancer, inflammation, insomnia, and diabetes. Understanding CRY function can lead to both prevention and treatment of these diseases. Taken together, our research will have a broad impact on agriculture and human health and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $518,400 )
2026	2026	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	8	5/26/2026	NON-COMPETING CONTINUATION	$518,400
														Subtotal = $518,400

Issue Date FY: 2025 ( Subtotal = $518,400 )
2025	2025	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	001	7	5/8/2025	NON-COMPETING CONTINUATION	$518,400
2025	2024	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	6	11/8/2024	COMPETING CONTINUATION	$0
														Subtotal = $518,400

Issue Date FY: 2024 ( Subtotal = $517,821 )
2024	2024	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	001	6	7/19/2024	COMPETING CONTINUATION	$518,400
2024	2021	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	5	4/16/2024	NON-COMPETING CONTINUATION	-$579
														Subtotal = $517,821

Issue Date FY: 2021 ( Subtotal = $480,000 )
2021	2021	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	5	7/22/2021	NON-COMPETING CONTINUATION	$480,000
														Subtotal = $480,000

Issue Date FY: 2020 ( Subtotal = $607,809 )
2020	2020	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	001	4	7/22/2020	SUPPLEMENT FOR EXPANSION	$127,809
2020	2020	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	4	7/17/2020	NON-COMPETING CONTINUATION	$480,000
														Subtotal = $607,809

Issue Date FY: 2019 ( Subtotal = $724,177 )
2019	2019	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	3	7/9/2019	NON-COMPETING CONTINUATION	$480,000
2019	2019	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	001	3	8/5/2019	SUPPLEMENT FOR EXPANSION	$244,177
														Subtotal = $724,177

Issue Date FY: 2018 ( Subtotal = $480,000 )
2018	2018	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	2	7/12/2018	NON-COMPETING CONTINUATION	$480,000
														Subtotal = $480,000

Issue Date FY: 2017 ( Subtotal = $480,000 )
2017	2017	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Biomedical Research and Research Training	000	1	8/4/2017	NEW	$480,000
														Subtotal = $480,000

Grand Total All Awards = $4,326,607

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The Role of Cryptochromes in environmental regulation of growth

Award Number: R35GM125003

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/04/2017

PERIOD OF PERFORMANCE END DATE: 05/31/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer