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Identification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune Cells

Award Number: R35GM124922
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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PROJECT SUMMARY/ABSTRACT This research program aims to bridge the gap between genomics data generation from clinical samples and our ability to infer and interpret intricate regulatory programs that underpin cell function and dysfunction in human cells. The Ucar laboratory develops and applies computational solutions to uncover complex regulatory programs in human cells and address previously inaccessible questions related to how disruptions in these programs affect human health and disease. The goal is to create computational tools that are versatile, easy to use and in keeping with the ever-increasing sophistication and complexity of NGS data. The current focus on the immunobiology of aging leverages the Principal Investigator's extensive training in computer science, epigenomics, and aging biology. Ongoing work with collaborators at The Jackson Laboratory and The University of Connecticut Health Center has led to multiple discoveries related to the genomic signatures of human immune aging, and has yielded numerous questions that form the basis for the proposed research program, including: 1) Which regulatory programs and regulatory interactions are disrupted with aging in which immune cells? 2) How do men and women age differently? 3) What are the putative genomic/clinical/immunological markers of healthy aging? To address these questions, this research program will focus on developing machine learning and network mining algorithms that enable integration of data from diverse sources, since complex regulatory interactions and diverse regulatory elements cannot be inferred from a single data type. Fueled by these tools, it will investigate the dynamics of regulatory programs in blood- derived human immune cells associated with aging through collaborations with clinicians, immunologists, and chromatin scientists. This research will advance our understanding of how immune responses are transcriptionally regulated, will facilitate the design of interventions to boost immune health in elderly and diseased individuals, and will yield computational resources useful to diverse areas of genomic medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$7,857 )
2023	2021	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	5	10/28/2022	NON-COMPETING CONTINUATION	-$7,203
2023	2021	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	001	5	5/15/2023	NON-COMPETING CONTINUATION	-$654
														Subtotal = -$7,857

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	5	5/17/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $464,920 )
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	5	8/3/2021	NON-COMPETING CONTINUATION	$464,920
														Subtotal = $464,920

Issue Date FY: 2020 ( Subtotal = $464,920 )
2020	2020	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	4	8/10/2020	NON-COMPETING CONTINUATION	$464,920
														Subtotal = $464,920

Issue Date FY: 2019 ( Subtotal = $468,156 )
2019	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	3	7/26/2019	NON-COMPETING CONTINUATION	$468,156
														Subtotal = $468,156

Issue Date FY: 2018 ( Subtotal = $476,047 )
2018	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	001	2	8/31/2018	SUPPLEMENT FOR EXPANSION	$27,290
2018	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	2	7/31/2018	NON-COMPETING CONTINUATION	$448,757
														Subtotal = $476,047

Issue Date FY: 2017 ( Subtotal = $471,007 )
2017	2017	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	1	7/31/2017	NEW	$471,007
														Subtotal = $471,007

Grand Total All Awards = $2,337,193

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Identification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune Cells

Award Number: R35GM124922

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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