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A Multifaceted Approach to Study Tissue and Cell Type Specific Molecular Mechanisms of the Host Response to Acute/Chronic Viral Infection

Award Number: R35GM124915
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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This proposal is for the purchase of the CFX Opus 384 Real-Time PCR System that will be for the NIGMS-funded laboratory at the University of Miami School of Medicine of Dr. Emmanuel Thomas (R35GM124915). Dr. Thomas is requesting funding to cover the cost of this PCR system. The ultra-sensitivity of the Real-Time PCR instrument would provide the laboratory with day-today capabilities to obtain large data sets of nucleic acid levels including DNA and RNA biomarkers of cellular function related to antiviral innate immunity. The laboratory does not currently have unrestricted access to these analytic capabilities. Additional investment in the MIRA funded project led by Dr. Thomas, from the NIGMS, would enable his research group to improve and enhance their cellular analytic techniques to meet and exceed the stated and emergent research objectives. Furthermore, since the PI is a relatively new investigators only recently receiving his first NIH R grants, this additional piece of equipment would additionally support him on his established trajectory of scientific success. Dr. Thomas received his NIGMS R35 grant in 2017 with funding starting on September 10, 2017. Given that his lab currently consists of a laboratory manager, a technician and three graduate students, the original grant budget was distributed to cover supplies and salaries for the laboratory team that includes the PI, until July 2028. Therefore, funding from the R35 grant has already been committed to support the daily activities of the laboratory for the next 4 years. Given these budgetary restrictions, initially, there were no funds available in the budget to request the purchase of specialized equipment to support the research objectives of the grant. Importantly, with the R35 currently providing a solid foundation of funding for daily standard laboratory activities, there is now an emergent need for increased analytic capabilities to support the research objectives that are becoming increasingly more sophisticated. In Dr. Thomas' Laboratory, this PCR system would be specifically used for quantitation of nucleic acid levels to study the cellular interactions that control host defense to viral infection as cells differentiate from multi-potent progenitors to terminally differentiated cells.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Biomedical Research and Research Training	000	7	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $414,350 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Biomedical Research and Research Training	001	7	7/22/2024	NON-COMPETING CONTINUATION	$383,750
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Biomedical Research and Research Training	002	7	9/6/2024	SUPPLEMENT FOR EXPANSION	$30,600
2024	2021	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Biomedical Research and Research Training	000	5	7/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $414,350

Issue Date FY: 2023 ( Subtotal = $383,750 )
2023	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	000	6	8/10/2023	COMPETING CONTINUATION	$383,750
														Subtotal = $383,750

Issue Date FY: 2021 ( Subtotal = $398,277 )
2021	2021	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	001	5	8/24/2021	SUPPLEMENT FOR EXPANSION	$14,527
2021	2021	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	000	5	8/23/2021	NON-COMPETING CONTINUATION	$383,750
														Subtotal = $398,277

Issue Date FY: 2020 ( Subtotal = $570,015 )
2020	2020	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	002	4	8/10/2020	NON-COMPETING CONTINUATION	$441,859
2020	2020	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	003	4	8/24/2020	SUPPLEMENT FOR EXPANSION	$74,600
2020	2020	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	000	3	12/5/2019	SUPPLEMENT FOR EXPANSION	$43,582
2020	2020	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	001	3	6/24/2020	SUPPLEMENT FOR EXPANSION	$9,974
														Subtotal = $570,015

Issue Date FY: 2019 ( Subtotal = $439,107 )
2019	2019	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	000	3	8/15/2019	NON-COMPETING CONTINUATION	$439,107
														Subtotal = $439,107

Issue Date FY: 2018 ( Subtotal = $545,842 )
2018	2018	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	000	2	8/30/2018	NON-COMPETING CONTINUATION	$383,750
2018	2018	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	002	2	9/4/2018	SUPPLEMENT FOR EXPANSION	$106,735
2018	2018	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	001	2	8/31/2018	SUPPLEMENT FOR EXPANSION	$55,357
														Subtotal = $545,842

Issue Date FY: 2017 ( Subtotal = $383,750 )
2017	2017	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Biomedical Research and Research Training	000	1	9/5/2017	NEW	$383,750
														Subtotal = $383,750

Grand Total All Awards = $3,135,091

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A Multifaceted Approach to Study Tissue and Cell Type Specific Molecular Mechanisms of the Host Response to Acute/Chronic Viral Infection

Award Number: R35GM124915

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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