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Exploring Single-Molecule Biophotonics for Ultrahigh-Resolution Spatiotemporal-Multiplexed Optical Microscopy

Award Number: R35GM124846
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary / Abstract The distribution and interactions of molecules in three-dimensionally organized cellular networks are fundamen- tal to the function of living systems. However, to date, a complete understanding of how local molecular mecha- nisms are integrated over larger scales to support tissue functions, or contribute to disease initiation, is still lacking. The challenges are mainly due to the limitations in imaging technology to provide molecular specificity, nanometer-scale resolution, ultrafast speed across larger volumes of tissue. To address the challenge, the pro- posed research program investigates the physical and engineering principles underlying optical imaging in com- plex biological materials, and utilizes these principles to develop new biophotonic tools for next-generation light microscopy. The objective of this proposal is to establish a research program on transformative bioimaging tech- nology for high-throughput extraction of single-molecule information in biological systems. Specifically, the pro- posed research program proceeds in three major directions to develop and apply enabling technologies for un- derstanding the ultrastructural architecture, fast dynamics, and spatiotemporal-multiplexed molecular information in complex biological systems: 1) Wavefront-engineered super-resolution microscopy to allow nanometer-scale imaging at and beyond the tis- sue level with isotropic 3D resolution and large imaging depth; 2) High-resolution light-field microscopy and computational super-resolution imaging to enable ultrafast, live im- aging of large-scale, volumetric biological dynamics and activities; and 3) Spatiotemporal-multiplexed imaging and a proof-of-principle investigation of the brain immune system. The research integrates and translates innovations in physical concepts, computational frameworks, and ad- vanced optical engineering and instrumentation into enabling technologies for biomedical investigations. The significant impact of the work will advance the imaging power across unexplored regimes in both space and time for a better understanding of the molecular basis for the functions of tissues and organisms. The spatiotemporal- multiplexed imaging of the brain immune system will lay the technological foundation for future systematic inves- tigations of the role of microglia in brain homeostasis, circuit formation, and disease initiation and protection. In the long term, the proposed program is expected to not only provide new insights for brain study, but also open up many new pathways to a broad range of biomedical research, and ultimately enable new discoveries to ad- dress challenges in human well-being.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	8	11/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $511,742 )
2024	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	7	6/4/2024	SUPPLEMENT FOR EXPANSION	$105,976
2024	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	001	8	7/16/2024	NON-COMPETING CONTINUATION	$405,766
2024	2021	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	002	5	7/16/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $511,742

Issue Date FY: 2023 ( Subtotal = $406,618 )
2023	2023	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	7	7/19/2023	NON-COMPETING CONTINUATION	$406,618
														Subtotal = $406,618

Issue Date FY: 2022 ( Subtotal = $407,446 )
2022	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	6	7/19/2022	COMPETING CONTINUATION	$407,446
														Subtotal = $407,446

Issue Date FY: 2021 ( Subtotal = $368,039 )
2021	2021	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	5	8/27/2021	NON-COMPETING CONTINUATION	$368,039
														Subtotal = $368,039

Issue Date FY: 2020 ( Subtotal = $368,039 )
2020	2020	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	4	9/1/2020	NON-COMPETING CONTINUATION	$368,039
														Subtotal = $368,039

Issue Date FY: 2019 ( Subtotal = $368,039 )
2019	2019	GEORGIA TECH RESEARCH CORPORATION	505 10TH ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	003	3	8/23/2019	NON-COMPETING CONTINUATION	$368,039
2019	2018	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	001	2	11/20/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$126,262
2019	2018	GEORGIA TECH RESEARCH CORPORATION	505 10TH ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	002	2	11/28/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2019	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	1	11/20/2018	NEW	-$126,262
														Subtotal = $368,039

Issue Date FY: 2018 ( Subtotal = $368,039 )
2018	2018	GEORGIA TECH RESEARCH CORPORATION	505 10TH ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	001	2	9/14/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$368,039
2018	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	1	9/13/2018	NEW	$0
														Subtotal = $368,039

Issue Date FY: 2017 ( Subtotal = $392,659 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Biomedical Research and Research Training	000	1	7/24/2017	NEW	$392,659
														Subtotal = $392,659

Grand Total All Awards = $3,190,621

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Exploring Single-Molecule Biophotonics for Ultrahigh-Resolution Spatiotemporal-Multiplexed Optical Microscopy

Award Number: R35GM124846

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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