Saturday, July 5, 2025 7/5/2025

Neuronal and molecular mechanisms underlying neural regulation of innate immunity

Award Number: R35GM124678
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2027

Group Awards By:

View Award Description

Neuronal and molecular mechanisms underlying neural regulation of innate immunity - Project Summary Although the integration of neurobiology into immunological research has just begun, it has already profoundly improved our understanding of immunology. By using the Caenorhabditis elegans model system, we have identified three specific neuro-immune regulatory circuits that are mediated by the G protein-coupled receptors OCTR-1, NPR-8, and NMUR-1, respectively. Our studies and others indicate that there could be a predetermined setpoint for internal immunity, like the setpoint for the human heart rate, and that the nervous system regulates immune responses to internal or external environmental changes and restores immune homeostasis by bringing immunity back to the setpoint. Considering this “setpoint for immune homeostasis” theory, we plan to investigate how the nervous system and immune system interact to achieve the resolution of infection and the specificity of innate immunity, two important but poorly understood issues in immunology. Previously, we have characterized the OCTR-1-dependent neuro-immune regulatory circuit in great detail and have revealed that NMUR-1 mediates the specificity of C. elegans innate immunity. Here, we propose studies to dissect the molecular and neuronal mechanisms underlying neural regulation of resolution in the context of the OCTR-1 circuit and to identify specific neurons, neural networks, and neural signals that regulate NMUR-1- mediated specificity of innate immunity. These studies will advance our understanding of how the nervous system controls both infection resolution and innate immune specificity as well as define key regulatory principles that govern neuro-immune relationships. Results from these studies could benefit the development of new treatments for infectious diseases and innate immune disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	8	11/8/2024	NON-COMPETING CONTINUATION	$0
2025	2022	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	002	6	1/15/2025	COMPETING CONTINUATION	$21,119
2025	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	001	5	1/15/2025	NON-COMPETING CONTINUATION	-$21,119
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $654,075 )
2024	2024	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	7	5/20/2024	SUPPLEMENT FOR EXPANSION	$233,325
2024	2024	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	001	8	9/5/2024	NON-COMPETING CONTINUATION	$420,750
														Subtotal = $654,075

Issue Date FY: 2023 ( Subtotal = $432,794 )
2023	2023	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	001	7	8/21/2023	NON-COMPETING CONTINUATION	$420,750
2023	2023	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	6	5/9/2023	SUPPLEMENT FOR EXPANSION	$12,044
														Subtotal = $432,794

Issue Date FY: 2022 ( Subtotal = $420,750 )
2022	2022	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	6	8/9/2022	COMPETING CONTINUATION	$420,750
														Subtotal = $420,750

Issue Date FY: 2021 ( Subtotal = $595,904 )
2021	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	001	5	8/12/2021	NON-COMPETING CONTINUATION	$382,500
2021	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	4	7/30/2021	SUPPLEMENT FOR EXPANSION	$213,404
														Subtotal = $595,904

Issue Date FY: 2020 ( Subtotal = $382,500 )
2020	2020	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	4	8/11/2020	NON-COMPETING CONTINUATION	$382,500
														Subtotal = $382,500

Issue Date FY: 2019 ( Subtotal = $382,500 )
2019	2019	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	3	8/22/2019	NON-COMPETING CONTINUATION	$382,500
														Subtotal = $382,500

Issue Date FY: 2018 ( Subtotal = $382,500 )
2018	2018	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	2	8/30/2018	NON-COMPETING CONTINUATION	$382,500
														Subtotal = $382,500

Issue Date FY: 2017 ( Subtotal = $382,500 )
2017	2017	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Biomedical Research and Research Training	000	1	9/12/2017	NEW	$382,500
														Subtotal = $382,500

Grand Total All Awards = $3,633,523

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Neuronal and molecular mechanisms underlying neural regulation of innate immunity

Award Number: R35GM124678

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer