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Anaerobic Chamber Administrative Supplement for R35

Award Number: R35GM124594
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2017
PERIOD OF PERFORMANCE END DATE: 07/31/2023

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Anaerobic Chamber Administrative Supplement for R35 - Project Summary/Abstract Studies of microorganisms have largely been carried out in free-floating (planktonic) cultures; however, the environmental and medical impacts of most microorganisms depend on their abilities to form resilient surface- associated microbial communities called biofilms. Biofilms are the predominant growth state of most microorganisms on biotic and abiotic surfaces. The overarching goal of my lab’s research program is to understand the molecular and mechanistic bases of microbial communities. We are interested in investigating how transcriptional networks underlie the regulation of gene expression during the development of microbial communities. Our overarching goals are to understand how these communities are regulated, how they are built, how their specialized properties are elaborated and maintained, and how these types of behaviors have evolved. We take systems biology approaches to address these biological questions and explore microbial communities at both the single-species as well as multi- species levels. The types of microorganisms we study include fungi, bacteria, and archaea, and vary from those that are found in the environment to commensals and opportunistic pathogens existing in the microbiota of mammalian hosts. Our central hypothesis is that there should be overlap in the molecular mechanisms used by microorganisms (even across kingdoms) to form microbial communities. This information will provide new insights into ways of treating biofilms in industrial and medical settings and, perhaps most importantly, in preventing them from forming in the first place. More broadly, this work may also shed light on the evolution of multicellularity in more recently evolved organisms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$3,507 )
2025	2021	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95343	MERCED	USA	Biomedical Research and Research Training	000	5	3/14/2025	NON-COMPETING CONTINUATION	-$2,616
2025	2021	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95343	MERCED	USA	Biomedical Research and Research Training	001	5	3/14/2025	SUPPLEMENT FOR EXPANSION	-$891
														Subtotal = -$3,507

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95343	MERCED	USA	Biomedical Research and Research Training	000	5	7/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $511,418 )
2021	2021	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95344	MERCED	USA	Biomedical Research and Research Training	000	5	7/29/2021	NON-COMPETING CONTINUATION	$381,418
2021	2021	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95344	MERCED	USA	Biomedical Research and Research Training	001	5	8/17/2021	SUPPLEMENT FOR EXPANSION	$130,000
														Subtotal = $511,418

Issue Date FY: 2020 ( Subtotal = $381,417 )
2020	2020	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95344	MERCED	USA	Biomedical Research and Research Training	000	4	7/28/2020	NON-COMPETING CONTINUATION	$381,417
														Subtotal = $381,417

Issue Date FY: 2019 ( Subtotal = $381,417 )
2019	2019	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95344	MERCED	USA	Biomedical Research and Research Training	000	3	7/22/2019	NON-COMPETING CONTINUATION	$381,417
														Subtotal = $381,417

Issue Date FY: 2018 ( Subtotal = $381,418 )
2018	2018	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95344	MERCED	USA	Biomedical Research and Research Training	000	2	7/23/2018	NON-COMPETING CONTINUATION	$381,418
														Subtotal = $381,418

Issue Date FY: 2017 ( Subtotal = $367,364 )
2017	2017	UNIVERSITY OF CALIFORNIA MERCED	5200 N LAKE RD	MERCED	CA	95343	MERCED	USA	Biomedical Research and Research Training	000	1	9/12/2017	NEW	$367,364
														Subtotal = $367,364

Grand Total All Awards = $2,019,527

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Anaerobic Chamber Administrative Supplement for R35

Award Number: R35GM124594

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2017

PERIOD OF PERFORMANCE END DATE: 07/31/2023

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