Sunday, December 22, 2024 12/22/2024

Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic Resolution

Award Number: R35GM122510
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract We aim to greatly extend our existing studies in the proposed period, capitalizing on the great advances in electron cryo-microscopy that have been due to improved direct electron detectors, better software, and faster computers. The studies will include pili and flagellar filaments from pathogenic bacteria, mating pili, type III and IV secretion systems, and archaeal viruses infecting hosts living in the most extreme environments. In addition, we will continue studies of small molecules and peptides that self-assemble into tubes and filaments, many with anticipated biomedical applications. Our work on actin and why the sequence has been so highly conserved will continue. By working on many disparate polymers, we expect to develop more general methods that can be applied by others to helical polymers in biology. Since large numbers of such polymers exist, ranging from cytoskeletal filaments to amyloid to helical viruses (such as Ebola) the potential significance of this work is enormous and likely to have a great impact.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	8	11/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $770,997 )
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	8	4/19/2024	SUPPLEMENT FOR EXPANSION	$18,501
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	002	8	6/19/2024	NON-COMPETING CONTINUATION	$75,249
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	8	4/18/2024	NON-COMPETING CONTINUATION	$677,247
														Subtotal = $770,997

Issue Date FY: 2023 ( Subtotal = $849,496 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	003	7	6/23/2023	SUPPLEMENT FOR EXPANSION	$74,005
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	004	7	6/26/2023	SUPPLEMENT FOR EXPANSION	$22,995
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	002	7	6/22/2023	NON-COMPETING CONTINUATION	$752,496
2023	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	6	11/22/2022	COMPETING CONTINUATION	$5,328
2023	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	5	11/22/2022	NON-COMPETING CONTINUATION	-$5,328
														Subtotal = $849,496

Issue Date FY: 2022 ( Subtotal = $901,104 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	6	5/6/2022	COMPETING CONTINUATION	$845,600
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	6	9/20/2022	SUPPLEMENT FOR EXPANSION	$55,504
														Subtotal = $901,104

Issue Date FY: 2021 ( Subtotal = $675,403 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	5	4/29/2021	NON-COMPETING CONTINUATION	$675,403
														Subtotal = $675,403

Issue Date FY: 2020 ( Subtotal = $675,403 )
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	4	4/30/2020	NON-COMPETING CONTINUATION	$675,403
														Subtotal = $675,403

Issue Date FY: 2019 ( Subtotal = $675,403 )
2019	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	3	5/3/2019	NON-COMPETING CONTINUATION	$675,403
														Subtotal = $675,403

Issue Date FY: 2018 ( Subtotal = $755,403 )
2018	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	2	9/21/2018	SUPPLEMENT FOR EXPANSION	$80,000
2018	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	2	4/24/2018	NON-COMPETING CONTINUATION	$675,403
														Subtotal = $755,403

Issue Date FY: 2017 ( Subtotal = $485,401 )
2017	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	1	4/25/2017	NEW	$485,401
														Subtotal = $485,401

Grand Total All Awards = $5,788,610

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Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic Resolution

Award Number: R35GM122510

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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